Epigenetic changes in gastroenteropancreatic neuroendocrine tumours

P. Mapelli, E. O. Aboagye, J. Stebbing, R. Sharma

Research output: Contribution to journalArticlepeer-review

Abstract

An understanding of epigenetic drivers of tumorigenesis has developed rapidly during the last years. The identification of these changes including DNA methylation and histone modifications in gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is a step forward in trying to define underlying biologic processes in this heterogeneous disease. The reversible nature of these changes represents a potential therapeutic target. We present an overview of the current knowledge of epigenetic alterations related to GEP-NETs, focusing on the influence and impact these changes have on pathogenesis and prognosis. The potential role of demethylating agents in the management of this patient population is discussed.

Original languageEnglish
Pages (from-to)4439-4447
Number of pages9
JournalOncogene
Volume34
Issue number34
DOIs
Publication statusPublished - Aug 20 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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