TY - JOUR
T1 - Epigenetic changes predisposing to type 2 diabetes in intrauterine growth retardation
AU - Liguori, Alice
AU - Puglianiello, Antonella
AU - Germani, Daniela
AU - Deodati, Annalisa
AU - Peschiaroli, Emanuela
AU - Cianfarani, Stefano
PY - 2010
Y1 - 2010
N2 - Epidemiologic studies have demonstrated an association between intrauterine growth retardation and a greater risk of chronic disease, including coronary heart disease, hypertension, stroke, and type 2 diabetes in adulthood. An adverse intrauterine environment may affect both growth and development of the organism, permanently programming endocrine and metabolic functions. One of the mechanisms of programming is the epigenetic modification of gene promoters involved in the control of key metabolic pathways. The aim of this review is to provide an overview of the experimental evidence showing the effects of early exposure to suboptimal environment on epigenome. The knowledge of the epigenetic markers of programming may allow the identification of susceptible individuals and the design of targeted prevention strategies.
AB - Epidemiologic studies have demonstrated an association between intrauterine growth retardation and a greater risk of chronic disease, including coronary heart disease, hypertension, stroke, and type 2 diabetes in adulthood. An adverse intrauterine environment may affect both growth and development of the organism, permanently programming endocrine and metabolic functions. One of the mechanisms of programming is the epigenetic modification of gene promoters involved in the control of key metabolic pathways. The aim of this review is to provide an overview of the experimental evidence showing the effects of early exposure to suboptimal environment on epigenome. The knowledge of the epigenetic markers of programming may allow the identification of susceptible individuals and the design of targeted prevention strategies.
KW - Diabetes
KW - Epigenetics
KW - Intrauterine growth retardation
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U2 - 10.3389/fendo.2010.00005
DO - 10.3389/fendo.2010.00005
M3 - Article
AN - SCOPUS:79955795551
VL - 1
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
IS - NOV
M1 - Article 5
ER -