Epigenetic changes predisposing to type 2 diabetes in intrauterine growth retardation

Alice Liguori; Antonella Puglianiello; Daniela Germani; Annalisa Deodati; Emanuela Peschiaroli; Stefano Cianfarani

doi:10.3389/fendo.2010.00005

Epigenetic changes predisposing to type 2 diabetes in intrauterine growth retardation

Alice Liguori, Antonella Puglianiello, Daniela Germani, Annalisa Deodati, Emanuela Peschiaroli, Stefano Cianfarani

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Epidemiologic studies have demonstrated an association between intrauterine growth retardation and a greater risk of chronic disease, including coronary heart disease, hypertension, stroke, and type 2 diabetes in adulthood. An adverse intrauterine environment may affect both growth and development of the organism, permanently programming endocrine and metabolic functions. One of the mechanisms of programming is the epigenetic modification of gene promoters involved in the control of key metabolic pathways. The aim of this review is to provide an overview of the experimental evidence showing the effects of early exposure to suboptimal environment on epigenome. The knowledge of the epigenetic markers of programming may allow the identification of susceptible individuals and the design of targeted prevention strategies.

Original language	English
Article number	Article 5
Journal	Frontiers in Endocrinology
Volume	1
Issue number	NOV
DOIs	https://doi.org/10.3389/fendo.2010.00005
Publication status	Published - 2010

Keywords

Diabetes
Epigenetics
Intrauterine growth retardation

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

Access to Document

10.3389/fendo.2010.00005

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abstract = "Epidemiologic studies have demonstrated an association between intrauterine growth retardation and a greater risk of chronic disease, including coronary heart disease, hypertension, stroke, and type 2 diabetes in adulthood. An adverse intrauterine environment may affect both growth and development of the organism, permanently programming endocrine and metabolic functions. One of the mechanisms of programming is the epigenetic modification of gene promoters involved in the control of key metabolic pathways. The aim of this review is to provide an overview of the experimental evidence showing the effects of early exposure to suboptimal environment on epigenome. The knowledge of the epigenetic markers of programming may allow the identification of susceptible individuals and the design of targeted prevention strategies.",

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AU - Liguori, Alice

AU - Puglianiello, Antonella

AU - Germani, Daniela

AU - Deodati, Annalisa

AU - Peschiaroli, Emanuela

AU - Cianfarani, Stefano

PY - 2010

Y1 - 2010

N2 - Epidemiologic studies have demonstrated an association between intrauterine growth retardation and a greater risk of chronic disease, including coronary heart disease, hypertension, stroke, and type 2 diabetes in adulthood. An adverse intrauterine environment may affect both growth and development of the organism, permanently programming endocrine and metabolic functions. One of the mechanisms of programming is the epigenetic modification of gene promoters involved in the control of key metabolic pathways. The aim of this review is to provide an overview of the experimental evidence showing the effects of early exposure to suboptimal environment on epigenome. The knowledge of the epigenetic markers of programming may allow the identification of susceptible individuals and the design of targeted prevention strategies.

AB - Epidemiologic studies have demonstrated an association between intrauterine growth retardation and a greater risk of chronic disease, including coronary heart disease, hypertension, stroke, and type 2 diabetes in adulthood. An adverse intrauterine environment may affect both growth and development of the organism, permanently programming endocrine and metabolic functions. One of the mechanisms of programming is the epigenetic modification of gene promoters involved in the control of key metabolic pathways. The aim of this review is to provide an overview of the experimental evidence showing the effects of early exposure to suboptimal environment on epigenome. The knowledge of the epigenetic markers of programming may allow the identification of susceptible individuals and the design of targeted prevention strategies.

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