Epigenetic mechanisms and endocannabinoid signalling

Claudio D'Addario, Andrea Di Francesco, Mariangela Pucci, Alessandro Finazzi Agrò, Mauro MacCarrone

Research output: Contribution to journalArticlepeer-review


The endocannabinoid system, composed of endogenous lipids, their target receptors and metabolic enzymes, has been implicated in multiple biological functions in health and disease, both in the central nervous system and in peripheral organs. Despite the exponential growth of experimental evidence on the key role of endocannabinoid signalling in basic cellular processes, and on its potential exploitation for therapeutic interventions, much remains to be clarified about the respective regulatory mechanisms. Epigenetics refers to a set of post-translational modifications that regulate gene expression without causing variation in DNA sequence, endowed with a major impact on signal transduction pathways. The epigenetic machinery includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs. Due to the reversibility of epigenetic changes, an emerging field of interest is the possibility of an 'epigenetic therapy' that could possibly be applied also to endocannabinoids. Here, we review current knowledge of epigenetic regulation of endocannabinoid system components under both physiological and pathological conditions, as well as the epigenetic changes induced by endocannabinoid signalling.

Original languageEnglish
Pages (from-to)1905-1917
Number of pages13
JournalFEBS Journal
Issue number9
Publication statusPublished - May 2013


  • cannabinoid receptors
  • DNA methylation
  • endocannabinoids
  • epigenetic mechanisms
  • histone modifications
  • metabolic enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology


Dive into the research topics of 'Epigenetic mechanisms and endocannabinoid signalling'. Together they form a unique fingerprint.

Cite this