Epigenetic mechanisms and endocannabinoid signalling

Claudio D'Addario, Andrea Di Francesco, Mariangela Pucci, Alessandro Finazzi Agrò, Mauro MacCarrone

Research output: Contribution to journalArticle

Abstract

The endocannabinoid system, composed of endogenous lipids, their target receptors and metabolic enzymes, has been implicated in multiple biological functions in health and disease, both in the central nervous system and in peripheral organs. Despite the exponential growth of experimental evidence on the key role of endocannabinoid signalling in basic cellular processes, and on its potential exploitation for therapeutic interventions, much remains to be clarified about the respective regulatory mechanisms. Epigenetics refers to a set of post-translational modifications that regulate gene expression without causing variation in DNA sequence, endowed with a major impact on signal transduction pathways. The epigenetic machinery includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs. Due to the reversibility of epigenetic changes, an emerging field of interest is the possibility of an 'epigenetic therapy' that could possibly be applied also to endocannabinoids. Here, we review current knowledge of epigenetic regulation of endocannabinoid system components under both physiological and pathological conditions, as well as the epigenetic changes induced by endocannabinoid signalling.

Original languageEnglish
Pages (from-to)1905-1917
Number of pages13
JournalFEBS Journal
Volume280
Issue number9
DOIs
Publication statusPublished - May 2013

Fingerprint

Endocannabinoids
Epigenomics
Histone Code
Signal transduction
Untranslated RNA
Nucleosomes
DNA sequences
Neurology
Gene expression
Histones
Machinery
DNA Methylation
Post Translational Protein Processing
Health
Signal Transduction
Lipids
Central Nervous System
Gene Expression
Enzymes
Therapeutics

Keywords

  • cannabinoid receptors
  • DNA methylation
  • endocannabinoids
  • epigenetic mechanisms
  • histone modifications
  • metabolic enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

D'Addario, C., Di Francesco, A., Pucci, M., Finazzi Agrò, A., & MacCarrone, M. (2013). Epigenetic mechanisms and endocannabinoid signalling. FEBS Journal, 280(9), 1905-1917. https://doi.org/10.1111/febs.12125

Epigenetic mechanisms and endocannabinoid signalling. / D'Addario, Claudio; Di Francesco, Andrea; Pucci, Mariangela; Finazzi Agrò, Alessandro; MacCarrone, Mauro.

In: FEBS Journal, Vol. 280, No. 9, 05.2013, p. 1905-1917.

Research output: Contribution to journalArticle

D'Addario, C, Di Francesco, A, Pucci, M, Finazzi Agrò, A & MacCarrone, M 2013, 'Epigenetic mechanisms and endocannabinoid signalling', FEBS Journal, vol. 280, no. 9, pp. 1905-1917. https://doi.org/10.1111/febs.12125
D'Addario C, Di Francesco A, Pucci M, Finazzi Agrò A, MacCarrone M. Epigenetic mechanisms and endocannabinoid signalling. FEBS Journal. 2013 May;280(9):1905-1917. https://doi.org/10.1111/febs.12125
D'Addario, Claudio ; Di Francesco, Andrea ; Pucci, Mariangela ; Finazzi Agrò, Alessandro ; MacCarrone, Mauro. / Epigenetic mechanisms and endocannabinoid signalling. In: FEBS Journal. 2013 ; Vol. 280, No. 9. pp. 1905-1917.
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