Epigenetic Mistakes in Neurodevelopmental Disorders

G Mastrototaro, M Zaghi, A Sessa

Research output: Contribution to journalArticle

Abstract

Epigenetics is the array of the chromatin modifications that customize in cell-, stage-, or condition-specific manner the information encloses in plain DNA molecules. Increasing evidences suggest the importance of epigenetic mechanisms for development and maintenance of central nervous system. In fact, a large number of newly discovered genetic causes of neurodevelopmental disorders such as intellectual disability, autism spectrum disorders, and many other syndromes are mutations within genes encoding for chromatin remodeling enzymes. Here, we review recent findings on the epigenetic origin of human diseases, with emphasis on disorders that affect development of the nervous system, and discuss novel therapeutic avenues that target epigenetic mechanisms. © 2017, Springer Science+Business Media New York.
Original languageEnglish
Pages (from-to)590-602
Number of pages13
JournalJournal of Molecular Neuroscience
Volume61
Issue number4
DOIs
Publication statusPublished - 2017

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