Epigenetic Programming and Risk: The Birthplace of Cardiovascular Disease?

Research output: Contribution to journalArticlepeer-review

Abstract

Epigenetics, through control of gene expression circuitries, plays important roles in various physiological processes such as stem cell differentiation and self renewal. This occurs during embryonic development, in different tissues, and in response to environmental stimuli. The language of epigenetic program is based on specific covalent modifications of DNA and chromatin. Thus, in addition to the individual identity, encoded by sequence of the four bases of the DNA, there is a cell type identity characterized by its positioning in the epigenetic "landscape". Aberrant changes in epigenetic marks induced by environmental cues may contribute to the development of abnormal phenotypes associated with different human diseases such as cancer, neurological disorders and inflammation. Most of the epigenetic studies have focused on embryonic development and cancer biology, while little has been done to explore the role of epigenetic mechanisms in the pathogenesis of cardiovascular disease. This review highlights our current knowledge of epigenetic gene regulation and the evidence that chromatin remodeling and histone modifications play key roles in the pathogenesis of cardiovascular disease through (re)programming of cardiovascular (stem) cells commitment, identity and function.

Original languageEnglish
Pages (from-to)241-253
Number of pages13
JournalStem Cell Reviews and Reports
Volume9
Issue number3
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Cardiovascular disease
  • Developmental plasticity
  • Differentiation
  • Epigenetic programming
  • Metabolic memory
  • Nutriepigenomics
  • Stem cells

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology

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