Abstract
Objective: Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. Methods: We have studied the gene expression status and the epigenetic regulation of ECS components in peripheral blood mononuclear cells (PBMCs) of subjects with late-onset AD (LOAD) and age-matched controls (CT). Results: We found an increase in fatty acid amide hydrolase (faah) gene expression in LOAD subjects (2.30±0.48) when compared to CT (1.00±0.14; *p
| Original language | English |
|---|---|
| Article number | e39186 |
| Journal | PLoS One |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 12 2012 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Epigenetic regulation of Fatty acid amide Hydrolase in Alzheimer disease. / D'Addario, Claudio; Di Francesco, Andrea; Arosio, Beatrice; Gussago, Cristina; Dell'Osso, Bernardo; Bari, Monica; Galimberti, Daniela; Scarpini, Elio; Altamura, A. Carlo; Mari, Daniela; Maccarrone, Mauro.
In: PLoS One, Vol. 7, No. 6, e39186, 12.06.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epigenetic regulation of Fatty acid amide Hydrolase in Alzheimer disease
AU - D'Addario, Claudio
AU - Di Francesco, Andrea
AU - Arosio, Beatrice
AU - Gussago, Cristina
AU - Dell'Osso, Bernardo
AU - Bari, Monica
AU - Galimberti, Daniela
AU - Scarpini, Elio
AU - Altamura, A. Carlo
AU - Mari, Daniela
AU - Maccarrone, Mauro
PY - 2012/6/12
Y1 - 2012/6/12
N2 - Objective: Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. Methods: We have studied the gene expression status and the epigenetic regulation of ECS components in peripheral blood mononuclear cells (PBMCs) of subjects with late-onset AD (LOAD) and age-matched controls (CT). Results: We found an increase in fatty acid amide hydrolase (faah) gene expression in LOAD subjects (2.30±0.48) when compared to CT (1.00±0.14; *p
AB - Objective: Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. Methods: We have studied the gene expression status and the epigenetic regulation of ECS components in peripheral blood mononuclear cells (PBMCs) of subjects with late-onset AD (LOAD) and age-matched controls (CT). Results: We found an increase in fatty acid amide hydrolase (faah) gene expression in LOAD subjects (2.30±0.48) when compared to CT (1.00±0.14; *p
UR - http://www.scopus.com/inward/record.url?scp=84862196266&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862196266&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0039186
DO - 10.1371/journal.pone.0039186
M3 - Article
C2 - 22720070
AN - SCOPUS:84862196266
VL - 7
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 6
M1 - e39186
ER -