Epigenetic regulation of Fatty acid amide Hydrolase in Alzheimer disease

Claudio D'Addario, Andrea Di Francesco, Beatrice Arosio, Cristina Gussago, Bernardo Dell'Osso, Monica Bari, Daniela Galimberti, Elio Scarpini, A. Carlo Altamura, Daniela Mari, Mauro Maccarrone

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. Methods: We have studied the gene expression status and the epigenetic regulation of ECS components in peripheral blood mononuclear cells (PBMCs) of subjects with late-onset AD (LOAD) and age-matched controls (CT). Results: We found an increase in fatty acid amide hydrolase (faah) gene expression in LOAD subjects (2.30±0.48) when compared to CT (1.00±0.14; *p

Original languageEnglish
Article numbere39186
JournalPLoS One
Volume7
Issue number6
DOIs
Publication statusPublished - Jun 12 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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