Epigenetic regulation of Fatty acid amide Hydrolase in Alzheimer disease

Claudio D'Addario; Andrea Di Francesco; Beatrice Arosio; Cristina Gussago; Bernardo Dell'Osso; Monica Bari; Daniela Galimberti; Elio Scarpini; A. Carlo Altamura; Daniela Mari; Mauro Maccarrone

doi:10.1371/journal.pone.0039186

Epigenetic regulation of Fatty acid amide Hydrolase in Alzheimer disease

Claudio D'Addario, Andrea Di Francesco, Beatrice Arosio, Cristina Gussago, Bernardo Dell'Osso, Monica Bari, Daniela Galimberti, Elio Scarpini, A. Carlo Altamura, Daniela Mari, Mauro Maccarrone

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. Methods: We have studied the gene expression status and the epigenetic regulation of ECS components in peripheral blood mononuclear cells (PBMCs) of subjects with late-onset AD (LOAD) and age-matched controls (CT). Results: We found an increase in fatty acid amide hydrolase (faah) gene expression in LOAD subjects (2.30±0.48) when compared to CT (1.00±0.14; *p

Original language	English
Article number	e39186
Journal	PLoS One
Volume	7
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0039186
Publication status	Published - Jun 12 2012

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Epigenetic regulation of Fatty acid amide Hydrolase in Alzheimer disease. / D'Addario, Claudio; Di Francesco, Andrea; Arosio, Beatrice; Gussago, Cristina; Dell'Osso, Bernardo; Bari, Monica; Galimberti, Daniela ; Scarpini, Elio; Altamura, A. Carlo; Mari, Daniela; Maccarrone, Mauro.

In: PLoS One, Vol. 7, No. 6, e39186, 12.06.2012.

Research output: Contribution to journal › Article › peer-review

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AU - Dell'Osso, Bernardo

AU - Bari, Monica

AU - Galimberti, Daniela

AU - Scarpini, Elio

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