Abstract
Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.
| Original language | English |
|---|---|
| Article number | e27722 |
| Journal | PLoS One |
| Volume | 6 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Epigenetic Regulation of miR-212 Expression in Lung Cancer. / Incoronato, Mariarosaria; Urso, Loredana; Portela, Ana; Laukkanen, Mikko O.; Soini, Ylermi; Quintavalle, Cristina; Keller, Simona; Esteller, Manel; Condorelli, Gerolama.
In: PLoS One, Vol. 6, No. 11, e27722, 2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epigenetic Regulation of miR-212 Expression in Lung Cancer
AU - Incoronato, Mariarosaria
AU - Urso, Loredana
AU - Portela, Ana
AU - Laukkanen, Mikko O.
AU - Soini, Ylermi
AU - Quintavalle, Cristina
AU - Keller, Simona
AU - Esteller, Manel
AU - Condorelli, Gerolama
PY - 2011
Y1 - 2011
N2 - Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.
AB - Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.
UR - http://www.scopus.com/inward/record.url?scp=84858777556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858777556&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0027722
DO - 10.1371/journal.pone.0027722
M3 - Article
VL - 6
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 11
M1 - e27722
ER -