Epigenetic Regulation of miR-212 Expression in Lung Cancer

Mariarosaria Incoronato; Loredana Urso; Ana Portela; Mikko O. Laukkanen; Ylermi Soini; Cristina Quintavalle; Simona Keller; Manel Esteller; Gerolama Condorelli

doi:10.1371/journal.pone.0027722

Epigenetic Regulation of miR-212 Expression in Lung Cancer

Mariarosaria Incoronato, Loredana Urso, Ana Portela, Mikko O. Laukkanen, Ylermi Soini, Cristina Quintavalle, Simona Keller, Manel Esteller, Gerolama Condorelli

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Abstract

Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.

Original language	English
Article number	e27722
Journal	PLoS One
Volume	6
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0027722
Publication status	Published - 2011

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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abstract = "Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.",

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AU - Incoronato, Mariarosaria

AU - Urso, Loredana

AU - Portela, Ana

AU - Laukkanen, Mikko O.

AU - Soini, Ylermi

AU - Quintavalle, Cristina

AU - Keller, Simona

AU - Esteller, Manel

AU - Condorelli, Gerolama

PY - 2011

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AB - Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.

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