Epigenetic Regulation of miR-212 Expression in Lung Cancer

Mariarosaria Incoronato; Loredana Urso; Ana Portela; Mikko O. Laukkanen; Ylermi Soini; Cristina Quintavalle; Simona Keller; Manel Esteller; Gerolama Condorelli

doi:10.1371/journal.pone.0027722

Epigenetic Regulation of miR-212 Expression in Lung Cancer

Mariarosaria Incoronato, Loredana Urso, Ana Portela, Mikko O. Laukkanen, Ylermi Soini, Cristina Quintavalle, Simona Keller, Manel Esteller, Gerolama Condorelli

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Abstract

Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.

Original language	English
Article number	e27722
Journal	PLoS One
Volume	6
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0027722
Publication status	Published - 2011

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ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Cite this

Incoronato, M., Urso, L., Portela, A., Laukkanen, M. O., Soini, Y., Quintavalle, C., Keller, S., Esteller, M., & Condorelli, G. (2011). Epigenetic Regulation of miR-212 Expression in Lung Cancer. PLoS One, 6(11), [e27722]. https://doi.org/10.1371/journal.pone.0027722

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AU - Quintavalle, Cristina

AU - Keller, Simona

AU - Esteller, Manel

AU - Condorelli, Gerolama

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10.1371/journal.pone.0027722