Epigenetic Regulation of miR-212 Expression in Lung Cancer

Mariarosaria Incoronato, Loredana Urso, Ana Portela, Mikko O. Laukkanen, Ylermi Soini, Cristina Quintavalle, Simona Keller, Manel Esteller, Gerolama Condorelli

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.

Original languageEnglish
Article numbere27722
JournalPLoS One
Volume6
Issue number11
DOIs
Publication statusPublished - 2011

Fingerprint

lung neoplasms
MicroRNAs
Epigenomics
epigenetics
Histones
Lung Neoplasms
Histone Code
DNA
microRNA
histones
disease severity
neoplasms
Neoplasms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Incoronato, M., Urso, L., Portela, A., Laukkanen, M. O., Soini, Y., Quintavalle, C., ... Condorelli, G. (2011). Epigenetic Regulation of miR-212 Expression in Lung Cancer. PLoS One, 6(11), [e27722]. https://doi.org/10.1371/journal.pone.0027722

Epigenetic Regulation of miR-212 Expression in Lung Cancer. / Incoronato, Mariarosaria; Urso, Loredana; Portela, Ana; Laukkanen, Mikko O.; Soini, Ylermi; Quintavalle, Cristina; Keller, Simona; Esteller, Manel; Condorelli, Gerolama.

In: PLoS One, Vol. 6, No. 11, e27722, 2011.

Research output: Contribution to journalArticle

Incoronato, M, Urso, L, Portela, A, Laukkanen, MO, Soini, Y, Quintavalle, C, Keller, S, Esteller, M & Condorelli, G 2011, 'Epigenetic Regulation of miR-212 Expression in Lung Cancer', PLoS One, vol. 6, no. 11, e27722. https://doi.org/10.1371/journal.pone.0027722
Incoronato, Mariarosaria ; Urso, Loredana ; Portela, Ana ; Laukkanen, Mikko O. ; Soini, Ylermi ; Quintavalle, Cristina ; Keller, Simona ; Esteller, Manel ; Condorelli, Gerolama. / Epigenetic Regulation of miR-212 Expression in Lung Cancer. In: PLoS One. 2011 ; Vol. 6, No. 11.
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