Epigenetic Regulation of miR-212 Expression in Lung Cancer

Mariarosaria Incoronato, Loredana Urso, Ana Portela, Mikko O. Laukkanen, Ylermi Soini, Cristina Quintavalle, Simona Keller, Manel Esteller, Gerolama Condorelli

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Abstract

Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.

Original languageEnglish
Article numbere27722
JournalPLoS One
Volume6
Issue number11
DOIs
Publication statusPublished - 2011

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Incoronato, M., Urso, L., Portela, A., Laukkanen, M. O., Soini, Y., Quintavalle, C., Keller, S., Esteller, M., & Condorelli, G. (2011). Epigenetic Regulation of miR-212 Expression in Lung Cancer. PLoS One, 6(11), [e27722]. https://doi.org/10.1371/journal.pone.0027722