Epigenetic-related therapeutic challenges in cardiovascular disease

Concetta Schiano, Maria Teresa Vietri, Vincenzo Grimaldi, Antonietta Picascia, Maria Rosaria De Pascale, Claudio Napoli

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Progress in human genetic and genomic research has led to the identification of genetic variants associated with specific cardiovascular diseases (CVDs), but the pathogenic mechanisms remain unclear. Recent studies have analyzed the involvement of epigenetic mechanisms such as DNA methylation and histone modifications in the development and progression of CVD. Preliminary work has investigated the correlations between DNA methylation, histone modifications, and RNA-based mechanisms with CVDs including atherosclerosis, heart failure (HF), myocardial infarction (MI), and cardiac hypertrophy. Remarkably, both in utero programming and postnatal hypercholesterolemia may affect the epigenetic signature in the human cardiovascular system, thereby providing novel early epigenetic-related pharmacological insights. Interestingly, some dietary compounds, including polyphenols, cocoa, and folic acid, can modulate DNA methylation status, whereas statins may promote epigenetic-based control in CVD prevention through histone modifications. We review recent findings on the epigenetic control of cardiovascular system and new challenges for therapeutic strategies in CVDs.

Original languageEnglish
Pages (from-to)226-235
Number of pages10
JournalTrends in Pharmacological Sciences
Volume36
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Fingerprint

Epigenomics
Histone Code
Cardiovascular Diseases
DNA Methylation
Histones
Cardiovascular system
Cardiovascular System
Cocoa
Therapeutics
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Genetic Research
Medical Genetics
Cardiomegaly
Polyphenols
Hypercholesterolemia
Folic Acid
Atherosclerosis
Heart Failure
Myocardial Infarction
Pharmacology

Keywords

  • atherosclerosis
  • cardiovascular disease
  • cardiovascular pharmacology
  • epigenetics
  • natural compounds
  • statins

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Epigenetic-related therapeutic challenges in cardiovascular disease. / Schiano, Concetta; Vietri, Maria Teresa; Grimaldi, Vincenzo; Picascia, Antonietta; Pascale, Maria Rosaria De; Napoli, Claudio.

In: Trends in Pharmacological Sciences, Vol. 36, No. 4, 01.04.2015, p. 226-235.

Research output: Contribution to journalArticle

Schiano, Concetta ; Vietri, Maria Teresa ; Grimaldi, Vincenzo ; Picascia, Antonietta ; Pascale, Maria Rosaria De ; Napoli, Claudio. / Epigenetic-related therapeutic challenges in cardiovascular disease. In: Trends in Pharmacological Sciences. 2015 ; Vol. 36, No. 4. pp. 226-235.
@article{f1267ab22c314050a3c8afc46a97a760,
title = "Epigenetic-related therapeutic challenges in cardiovascular disease",
abstract = "Progress in human genetic and genomic research has led to the identification of genetic variants associated with specific cardiovascular diseases (CVDs), but the pathogenic mechanisms remain unclear. Recent studies have analyzed the involvement of epigenetic mechanisms such as DNA methylation and histone modifications in the development and progression of CVD. Preliminary work has investigated the correlations between DNA methylation, histone modifications, and RNA-based mechanisms with CVDs including atherosclerosis, heart failure (HF), myocardial infarction (MI), and cardiac hypertrophy. Remarkably, both in utero programming and postnatal hypercholesterolemia may affect the epigenetic signature in the human cardiovascular system, thereby providing novel early epigenetic-related pharmacological insights. Interestingly, some dietary compounds, including polyphenols, cocoa, and folic acid, can modulate DNA methylation status, whereas statins may promote epigenetic-based control in CVD prevention through histone modifications. We review recent findings on the epigenetic control of cardiovascular system and new challenges for therapeutic strategies in CVDs.",
keywords = "atherosclerosis, cardiovascular disease, cardiovascular pharmacology, epigenetics, natural compounds, statins",
author = "Concetta Schiano and Vietri, {Maria Teresa} and Vincenzo Grimaldi and Antonietta Picascia and Pascale, {Maria Rosaria De} and Claudio Napoli",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.tips.2015.02.005",
language = "English",
volume = "36",
pages = "226--235",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Epigenetic-related therapeutic challenges in cardiovascular disease

AU - Schiano, Concetta

AU - Vietri, Maria Teresa

AU - Grimaldi, Vincenzo

AU - Picascia, Antonietta

AU - Pascale, Maria Rosaria De

AU - Napoli, Claudio

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Progress in human genetic and genomic research has led to the identification of genetic variants associated with specific cardiovascular diseases (CVDs), but the pathogenic mechanisms remain unclear. Recent studies have analyzed the involvement of epigenetic mechanisms such as DNA methylation and histone modifications in the development and progression of CVD. Preliminary work has investigated the correlations between DNA methylation, histone modifications, and RNA-based mechanisms with CVDs including atherosclerosis, heart failure (HF), myocardial infarction (MI), and cardiac hypertrophy. Remarkably, both in utero programming and postnatal hypercholesterolemia may affect the epigenetic signature in the human cardiovascular system, thereby providing novel early epigenetic-related pharmacological insights. Interestingly, some dietary compounds, including polyphenols, cocoa, and folic acid, can modulate DNA methylation status, whereas statins may promote epigenetic-based control in CVD prevention through histone modifications. We review recent findings on the epigenetic control of cardiovascular system and new challenges for therapeutic strategies in CVDs.

AB - Progress in human genetic and genomic research has led to the identification of genetic variants associated with specific cardiovascular diseases (CVDs), but the pathogenic mechanisms remain unclear. Recent studies have analyzed the involvement of epigenetic mechanisms such as DNA methylation and histone modifications in the development and progression of CVD. Preliminary work has investigated the correlations between DNA methylation, histone modifications, and RNA-based mechanisms with CVDs including atherosclerosis, heart failure (HF), myocardial infarction (MI), and cardiac hypertrophy. Remarkably, both in utero programming and postnatal hypercholesterolemia may affect the epigenetic signature in the human cardiovascular system, thereby providing novel early epigenetic-related pharmacological insights. Interestingly, some dietary compounds, including polyphenols, cocoa, and folic acid, can modulate DNA methylation status, whereas statins may promote epigenetic-based control in CVD prevention through histone modifications. We review recent findings on the epigenetic control of cardiovascular system and new challenges for therapeutic strategies in CVDs.

KW - atherosclerosis

KW - cardiovascular disease

KW - cardiovascular pharmacology

KW - epigenetics

KW - natural compounds

KW - statins

UR - http://www.scopus.com/inward/record.url?scp=84940005171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940005171&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2015.02.005

DO - 10.1016/j.tips.2015.02.005

M3 - Article

C2 - 25758254

AN - SCOPUS:84940005171

VL - 36

SP - 226

EP - 235

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 4

ER -