Abstract
Progress in human genetic and genomic research has led to the identification of genetic variants associated with specific cardiovascular diseases (CVDs), but the pathogenic mechanisms remain unclear. Recent studies have analyzed the involvement of epigenetic mechanisms such as DNA methylation and histone modifications in the development and progression of CVD. Preliminary work has investigated the correlations between DNA methylation, histone modifications, and RNA-based mechanisms with CVDs including atherosclerosis, heart failure (HF), myocardial infarction (MI), and cardiac hypertrophy. Remarkably, both in utero programming and postnatal hypercholesterolemia may affect the epigenetic signature in the human cardiovascular system, thereby providing novel early epigenetic-related pharmacological insights. Interestingly, some dietary compounds, including polyphenols, cocoa, and folic acid, can modulate DNA methylation status, whereas statins may promote epigenetic-based control in CVD prevention through histone modifications. We review recent findings on the epigenetic control of cardiovascular system and new challenges for therapeutic strategies in CVDs.
| Original language | English |
|---|---|
| Pages (from-to) | 226-235 |
| Number of pages | 10 |
| Journal | Trends in Pharmacological Sciences |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2015 |
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Keywords
- atherosclerosis
- cardiovascular disease
- cardiovascular pharmacology
- epigenetics
- natural compounds
- statins
ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Epigenetic-related therapeutic challenges in cardiovascular disease. / Schiano, Concetta; Vietri, Maria Teresa; Grimaldi, Vincenzo; Picascia, Antonietta; Pascale, Maria Rosaria De; Napoli, Claudio.
In: Trends in Pharmacological Sciences, Vol. 36, No. 4, 01.04.2015, p. 226-235.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epigenetic-related therapeutic challenges in cardiovascular disease
AU - Schiano, Concetta
AU - Vietri, Maria Teresa
AU - Grimaldi, Vincenzo
AU - Picascia, Antonietta
AU - Pascale, Maria Rosaria De
AU - Napoli, Claudio
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Progress in human genetic and genomic research has led to the identification of genetic variants associated with specific cardiovascular diseases (CVDs), but the pathogenic mechanisms remain unclear. Recent studies have analyzed the involvement of epigenetic mechanisms such as DNA methylation and histone modifications in the development and progression of CVD. Preliminary work has investigated the correlations between DNA methylation, histone modifications, and RNA-based mechanisms with CVDs including atherosclerosis, heart failure (HF), myocardial infarction (MI), and cardiac hypertrophy. Remarkably, both in utero programming and postnatal hypercholesterolemia may affect the epigenetic signature in the human cardiovascular system, thereby providing novel early epigenetic-related pharmacological insights. Interestingly, some dietary compounds, including polyphenols, cocoa, and folic acid, can modulate DNA methylation status, whereas statins may promote epigenetic-based control in CVD prevention through histone modifications. We review recent findings on the epigenetic control of cardiovascular system and new challenges for therapeutic strategies in CVDs.
AB - Progress in human genetic and genomic research has led to the identification of genetic variants associated with specific cardiovascular diseases (CVDs), but the pathogenic mechanisms remain unclear. Recent studies have analyzed the involvement of epigenetic mechanisms such as DNA methylation and histone modifications in the development and progression of CVD. Preliminary work has investigated the correlations between DNA methylation, histone modifications, and RNA-based mechanisms with CVDs including atherosclerosis, heart failure (HF), myocardial infarction (MI), and cardiac hypertrophy. Remarkably, both in utero programming and postnatal hypercholesterolemia may affect the epigenetic signature in the human cardiovascular system, thereby providing novel early epigenetic-related pharmacological insights. Interestingly, some dietary compounds, including polyphenols, cocoa, and folic acid, can modulate DNA methylation status, whereas statins may promote epigenetic-based control in CVD prevention through histone modifications. We review recent findings on the epigenetic control of cardiovascular system and new challenges for therapeutic strategies in CVDs.
KW - atherosclerosis
KW - cardiovascular disease
KW - cardiovascular pharmacology
KW - epigenetics
KW - natural compounds
KW - statins
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UR - http://www.scopus.com/inward/citedby.url?scp=84940005171&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2015.02.005
DO - 10.1016/j.tips.2015.02.005
M3 - Article
C2 - 25758254
AN - SCOPUS:84940005171
VL - 36
SP - 226
EP - 235
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 4
ER -