Epigenetics and type 1 diabetes: mechanisms and translational applications

Alberto Zullo, Linda Sommese, Gianfranco Nicoletti, Francesco Donatelli, Francesco P. Mancini, Claudio Napoli

Research output: Contribution to journalReview articlepeer-review

Abstract

Type 1 diabetes (T1D) is an irreversible degenerative disease with severe complications such as heart disease, nephropathy, neuropathy, and retinopathy. Although exogenous insulin administration is a life-saving therapy, it does not cure the disease. This review addresses the epigenetic mechanisms responsible for the development of T1D and discusses epigenetic-based strategies for prevention and treatment of the disease. We describe novel epigenetic biomarkers for the identification of susceptible individuals and the establishment of innovative therapies with epidrugs and cell therapy to regenerate the lost β-cells. Despite the wealth of promising data regarding the potential benefits of epigenetic tools to reduce the burden of T1D, clinical trials are still very few, and this issue needs to be resolved in the near future.

Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalTranslational Research
Volume185
DOIs
Publication statusPublished - Jul 1 2017

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical

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