Epigenetics, miRNAs, and human cancer: A new chapter in human gene regulation

Nicola Valeri, Ivan Vannini, Francesca Fanini, Federica Calore, Brett Adair, Muller Fabbri

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer is a genetic and epigenetic disease. MicroRNAs (miRNAs), a class of small noncoding RNAs, have been shown to be deregulated in many diseases including cancer. An intertwined connection between epigenetics and miRNAs has been supported by the recent identification of a specific subgroup of miRNAs called "epi-miRNAs" that can directly and indirectly modulate the activity of the epigenetic machinery. The complexity of this connection is enhanced by the epigenetic regulation of miRNA expression that generates a fine regulatory feedback loop. This review focuses on how epigenetics affects the miRNome and how the recently identified epi-miRNAs regulate the epigenome in human cancers, ultimately contributing to human carcinogenesis.

Original languageEnglish
Pages (from-to)573-580
Number of pages8
JournalMammalian Genome
Volume20
Issue number9-10
DOIs
Publication statusPublished - Oct 2009

ASJC Scopus subject areas

  • Genetics

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