TY - JOUR
T1 - Epigenetics, miRNAs, and human cancer
T2 - A new chapter in human gene regulation
AU - Valeri, Nicola
AU - Vannini, Ivan
AU - Fanini, Francesca
AU - Calore, Federica
AU - Adair, Brett
AU - Fabbri, Muller
PY - 2009/10
Y1 - 2009/10
N2 - Cancer is a genetic and epigenetic disease. MicroRNAs (miRNAs), a class of small noncoding RNAs, have been shown to be deregulated in many diseases including cancer. An intertwined connection between epigenetics and miRNAs has been supported by the recent identification of a specific subgroup of miRNAs called "epi-miRNAs" that can directly and indirectly modulate the activity of the epigenetic machinery. The complexity of this connection is enhanced by the epigenetic regulation of miRNA expression that generates a fine regulatory feedback loop. This review focuses on how epigenetics affects the miRNome and how the recently identified epi-miRNAs regulate the epigenome in human cancers, ultimately contributing to human carcinogenesis.
AB - Cancer is a genetic and epigenetic disease. MicroRNAs (miRNAs), a class of small noncoding RNAs, have been shown to be deregulated in many diseases including cancer. An intertwined connection between epigenetics and miRNAs has been supported by the recent identification of a specific subgroup of miRNAs called "epi-miRNAs" that can directly and indirectly modulate the activity of the epigenetic machinery. The complexity of this connection is enhanced by the epigenetic regulation of miRNA expression that generates a fine regulatory feedback loop. This review focuses on how epigenetics affects the miRNome and how the recently identified epi-miRNAs regulate the epigenome in human cancers, ultimately contributing to human carcinogenesis.
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U2 - 10.1007/s00335-009-9206-5
DO - 10.1007/s00335-009-9206-5
M3 - Article
C2 - 19697081
AN - SCOPUS:72849147757
VL - 20
SP - 573
EP - 580
JO - Mammalian Genome
JF - Mammalian Genome
SN - 0938-8990
IS - 9-10
ER -