Epigenetics of human parathyroid tumors

Chiara Verdelli, Sabrina Corbetta

Research output: Contribution to journalArticle

Abstract

Parathyroid tumors are common endocrine neoplasia associated with primary hyperparathyroidism, a metabolic disorder sustained by parathormone hypersecretion. The epigenetic scenario in parathyroid tumors is beginning to be decoded. Here, main findings are reviewed: hypermethylation of specific DNA CpG islands has been described, despite global DNA promoter hypomethylation was not detectable; embryonic-related miRNAs, belonging to the C19MC and miR-371-373 clusters, and miR-296, are deregulated; expression of histone H1.2 and H2B is increased; expression of histone methyltransferase EZH2, BMI1 and RIZ1 is impaired; the tumor suppressor HIC1, MEN1 and CDC73 gene products, key molecules in parathyroid tumorigenesis, may be involved in epigenetic aberrant changes. Epigenetic changes are more frequent and more consistent in parathyroid malignancies, and positively correlated with severity of primary hyperparathyroidism.
Original languageEnglish
Pages (from-to)103-111
Number of pages9
JournalInternational Journal of Endocrine Oncology
Volume4
Issue number2
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Epigenomics
Primary Hyperparathyroidism
Neoplasms
Multiple Endocrine Neoplasia Type 1
CpG Islands
DNA
Parathyroid Hormone
MicroRNAs
Histones
Carcinogenesis
Genes

Keywords

  • DNA methylation
  • histone
  • histone methyltransferases
  • miRNAs
  • parathyroid tumors
  • primary hyperparathyroidism

Cite this

Epigenetics of human parathyroid tumors. / Verdelli, Chiara; Corbetta, Sabrina.

In: International Journal of Endocrine Oncology, Vol. 4, No. 2, 01.05.2017, p. 103-111.

Research output: Contribution to journalArticle

@article{94b86ca9fb31487db0df2bc39d3a8c09,
title = "Epigenetics of human parathyroid tumors",
abstract = "Parathyroid tumors are common endocrine neoplasia associated with primary hyperparathyroidism, a metabolic disorder sustained by parathormone hypersecretion. The epigenetic scenario in parathyroid tumors is beginning to be decoded. Here, main findings are reviewed: hypermethylation of specific DNA CpG islands has been described, despite global DNA promoter hypomethylation was not detectable; embryonic-related miRNAs, belonging to the C19MC and miR-371-373 clusters, and miR-296, are deregulated; expression of histone H1.2 and H2B is increased; expression of histone methyltransferase EZH2, BMI1 and RIZ1 is impaired; the tumor suppressor HIC1, MEN1 and CDC73 gene products, key molecules in parathyroid tumorigenesis, may be involved in epigenetic aberrant changes. Epigenetic changes are more frequent and more consistent in parathyroid malignancies, and positively correlated with severity of primary hyperparathyroidism.",
keywords = "DNA methylation, histone, histone methyltransferases, miRNAs, parathyroid tumors, primary hyperparathyroidism",
author = "Chiara Verdelli and Sabrina Corbetta",
year = "2017",
month = "5",
day = "1",
doi = "10.2217/ije-2017-0002",
language = "English",
volume = "4",
pages = "103--111",
journal = "International Journal of Endocrine Oncology",
issn = "2045-0869",
publisher = "Future Medicine Ltd.",
number = "2",

}

TY - JOUR

T1 - Epigenetics of human parathyroid tumors

AU - Verdelli, Chiara

AU - Corbetta, Sabrina

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Parathyroid tumors are common endocrine neoplasia associated with primary hyperparathyroidism, a metabolic disorder sustained by parathormone hypersecretion. The epigenetic scenario in parathyroid tumors is beginning to be decoded. Here, main findings are reviewed: hypermethylation of specific DNA CpG islands has been described, despite global DNA promoter hypomethylation was not detectable; embryonic-related miRNAs, belonging to the C19MC and miR-371-373 clusters, and miR-296, are deregulated; expression of histone H1.2 and H2B is increased; expression of histone methyltransferase EZH2, BMI1 and RIZ1 is impaired; the tumor suppressor HIC1, MEN1 and CDC73 gene products, key molecules in parathyroid tumorigenesis, may be involved in epigenetic aberrant changes. Epigenetic changes are more frequent and more consistent in parathyroid malignancies, and positively correlated with severity of primary hyperparathyroidism.

AB - Parathyroid tumors are common endocrine neoplasia associated with primary hyperparathyroidism, a metabolic disorder sustained by parathormone hypersecretion. The epigenetic scenario in parathyroid tumors is beginning to be decoded. Here, main findings are reviewed: hypermethylation of specific DNA CpG islands has been described, despite global DNA promoter hypomethylation was not detectable; embryonic-related miRNAs, belonging to the C19MC and miR-371-373 clusters, and miR-296, are deregulated; expression of histone H1.2 and H2B is increased; expression of histone methyltransferase EZH2, BMI1 and RIZ1 is impaired; the tumor suppressor HIC1, MEN1 and CDC73 gene products, key molecules in parathyroid tumorigenesis, may be involved in epigenetic aberrant changes. Epigenetic changes are more frequent and more consistent in parathyroid malignancies, and positively correlated with severity of primary hyperparathyroidism.

KW - DNA methylation

KW - histone

KW - histone methyltransferases

KW - miRNAs

KW - parathyroid tumors

KW - primary hyperparathyroidism

U2 - 10.2217/ije-2017-0002

DO - 10.2217/ije-2017-0002

M3 - Article

VL - 4

SP - 103

EP - 111

JO - International Journal of Endocrine Oncology

JF - International Journal of Endocrine Oncology

SN - 2045-0869

IS - 2

ER -