Modificazioni epigenetiche nell'esposizione a basse dosi di benzene

Translated title of the contribution: Epigenic modifications associated with low benzene exposure

Silvia Fustinoni, Valentina Bollati, Pier Alberto Bertazzi

Research output: Contribution to journalArticle

Abstract

DNA methylation, mitochondrial DNA copy number and telomeres shortening are cellular modifications associated with an increasing number of tumors, cardiovascular and aging diseases. In our studies these modifications were evaluated in subjects occupationally exposed to low levels of benzene and in the general population. In peripheral blood lymphocytes a decrease of DNA methylation with the increase of personal benzene exposure was found, both in Alu and LINE-1 repetitive elements, and in the global DNA. Telomere length shortening in subjects exposed to traffic exhausts and an increase in mitochondrial DNA copy number correlated to benzene exposure was also found. DNA methylation measured in specimen repeats collected at intervals of 8 years decreased more markedly in exposed subjects than in controls. Our studies highlighted the association of epigenetic modifications of DNA with low benzene exposure.

Translated title of the contributionEpigenic modifications associated with low benzene exposure
Original languageItalian
Pages (from-to)263-267
Number of pages5
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume35
Issue number4
Publication statusPublished - Oct 2013

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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