Epigenome programming by Polycomb and Trithorax proteins

Filippo M. Cernilogar, Valerio Orlando

Research output: Contribution to journalArticle

Abstract

Polycomb group (PcG) and Trithorax group (TrxG) proteins work, respectively, to maintain repressed or active transcription states of developmentally regulated genes through cell division. Data accumulated in the recent years have increased our understanding of the mechanisms by which PcG and TrxG proteins regulate gene expression. The discovery that histone methylation can serve as a specific mark for PcG and TrxG complexes has provided new insight into the mechanistic function of this cell-memory system.

Original languageEnglish
Pages (from-to)322-331
Number of pages10
JournalBiochemistry and Cell Biology
Volume83
Issue number3
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Cell memory
  • Epigenome
  • Noncoding RNA
  • Polycomb
  • RNAi
  • Trithorax

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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