Epilepsia partialis continua in type 1 diabetes: Evolution into epileptic encephalopathy with continuous spike-waves during slow sleep

Maria Giuseppina Baglietto, Maria Margherita Mancardi, Alessandro Giannattasio, Nicola Minuto, Andrea Rossi, Giuseppe Capovilla, Edvige Veneselli, Renata Lorini, Giuseppe D'Annunzio

Research output: Contribution to journalArticle

Abstract

Hyperglycemic status may be rarely complicated by Epilepsia partialis continua (EPC) that usually responds to metabolic normalization. Anti-glutamic acid decarboxylase antibodies (GAD-Ab) play a pivotal role in the autoimmune process that leads to clinical onset of type 1 diabetes mellitus (T1DM). GAD-Ab have been recently reported in association with rare forms of refractory epilepsy, with or without association to T1DM. Here we describe a young patient who developed EPC five months after T1DM onset; GAD-Ab were detected in his cerebrospinal fluid with evidence of oligoclonal bands. His epileptic disorder evolved over time into drug-resistant epilepsy with continuous spike-waves during slow sleep and severe behavioral impairment. The role of both metabolic imbalance and GAD autoimmunity is discussed.

Original languageEnglish
Pages (from-to)509-512
Number of pages4
JournalNeurological Sciences
Volume30
Issue number6
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Continuous spike-waves during slow sleep
  • Diabetes
  • Epilepsia partialis continua
  • Refractory epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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