Anti-GAD antibodies may decrease the conversion into GABA with outweighting of excitatory neurotransmitters. Anti-GAD are mainly implicated in the pathogenesis of type 1 diabetes, but have been recently described in association with focal epilepsy. We retrospectively investigated frequency and type of epilepsy among diabetic patient series (n = 286) followed at our Hospital, with the attempt to find a correlation with serum anti-GAD. Seven patients presented idiopathic/cryptogenic epilepsy: 4 of the generalized type, 2 focal and 1 with epileptic encephalopathy (4/7 were positive for anti-GAD).
|Translated title of the contribution||Epilepsy and anti-GAD in T1DM: Looking for a link|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 2008|
ASJC Scopus subject areas
- Clinical Neurology