Epilepsy in chromosomal abnormalities: An Italian sample

Antonia Parmeggiani, Annio Posar, Simona Giovannini, Paola Giovanardi-Rossi

Research output: Contribution to journalArticle

Abstract

Epilepsy is common in chromosomal abnormalities, but systematic studies are scanty. We describe an Italian sample of patients with chromosomopathies to establish epilepsy occurrence and clinical electroencephalographic (EEG) features. Forty-five patients with different types of chromosomal abnormalities were analyzed to examine different variables in patients with epilepsy (group 1) and without (group 2) and to compare the types of epilepsy in our cases with respect to a nonselected sample of Italian people with epilepsy. Epilepsy occurred in 51.1% (group 1) of cases and prevailed in autosomal abnormalities but without a statistical significance (P > .05). There was a prevalence of EEG paroxysmal abnormalities in group 1 (P <.0001); continuous spike-waves during sleep were observed in three cases. Profound mental retardation prevailed in group 1 (P <.001) and mild mental retardation in group 2 (P <.05). Generalized epilepsies prevailed significantly (P <.00001). A high-resolution karyotype should be undertaken in all patients with epilepsy presenting with mental retardation when an obvious etiology is not available.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalJournal of Child Neurology
Volume20
Issue number5
Publication statusPublished - May 2005

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Chromosome Aberrations
Epilepsy
Intellectual Disability
Generalized Epilepsy
Karyotype
Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Parmeggiani, A., Posar, A., Giovannini, S., & Giovanardi-Rossi, P. (2005). Epilepsy in chromosomal abnormalities: An Italian sample. Journal of Child Neurology, 20(5), 419-423.

Epilepsy in chromosomal abnormalities : An Italian sample. / Parmeggiani, Antonia; Posar, Annio; Giovannini, Simona; Giovanardi-Rossi, Paola.

In: Journal of Child Neurology, Vol. 20, No. 5, 05.2005, p. 419-423.

Research output: Contribution to journalArticle

Parmeggiani, A, Posar, A, Giovannini, S & Giovanardi-Rossi, P 2005, 'Epilepsy in chromosomal abnormalities: An Italian sample', Journal of Child Neurology, vol. 20, no. 5, pp. 419-423.
Parmeggiani A, Posar A, Giovannini S, Giovanardi-Rossi P. Epilepsy in chromosomal abnormalities: An Italian sample. Journal of Child Neurology. 2005 May;20(5):419-423.
Parmeggiani, Antonia ; Posar, Annio ; Giovannini, Simona ; Giovanardi-Rossi, Paola. / Epilepsy in chromosomal abnormalities : An Italian sample. In: Journal of Child Neurology. 2005 ; Vol. 20, No. 5. pp. 419-423.
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