Epilepsy in patients with pervasive developmental disorder not otherwise specified

Antonia Parmeggiani, Annio Posar, Chiara Antolini, Cristina Maria Scaduto, Margherita Santucci, Paola Giovanardi-Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Data on epilepsy in pervasive developmental disorder not otherwise specified are few and scanty. Seventy-seven patients with pervasive developmental disorder not otherwise specified were compared with 77 with autistic disorder, matched for age and sex. The 2 groups were divided into 3 subgroups each: A, without electroencephalography (EEG) paroxysmal abnormalities or epilepsy; B, with EEG paroxysmal abnormalities without epilepsy; and C, with epilepsy. Mild mental retardation (P <.01), pathological neurological examination (P <.05), cerebral lesions (P <.01), abnormal EEG background activity (P <.001), and associated genetic pathologies (P <.01) were more common in pervasive developmental disorder not otherwise specified. Familial antecedents for epilepsy prevailed in subgroup C (P <.01). Epilepsy occurred in 35.1% of patients with pervasive developmental disorder not otherwise specified, with no statistically significant difference compared with autistic disorder. The mean age of seizure onset was earlier (2 years 8 months) in pervasive developmental disorder not otherwise specified (P <.000). Seizure outcome was better in autistic disorder. Genetic diseases and cerebral lesions should be investigated in pervasive developmental disorder not otherwise specified to clarify the etiological and clinical features.

Original languageEnglish
Pages (from-to)1198-1203
Number of pages6
JournalJournal of Child Neurology
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Autism
  • Epilepsy
  • Pervasive developmental disorder not otherwise specified

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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