TY - JOUR
T1 - Epilepsy surgery in tuberous sclerosis complex
T2 - Early predictive elements and outcome
AU - Teutonico, F.
AU - Mai, R.
AU - Devinsky, O.
AU - Lo Russo, G.
AU - Weiner, H. L.
AU - Borrelli, P.
AU - Balottin, U.
AU - Veggiotti, P.
PY - 2008
Y1 - 2008
N2 - Aim: The aim of the study was to evaluate the surgical treatment of epilepsy and detection of possible early surgery predictive elements in patients with tuberous sclerosis complex (TSC). Materials and methods: Forty-two TSC patients with epilepsy were selected and divided into two main groups: definite and fruste forms. Definite forms were divided into different groups: patients with pharmacologically controlled epilepsy, patients with pharmacoresistant epilepsy excluded from surgery after an extensive presurgical assessment, and patients with a pharmacoresistant epilepsy who underwent surgery. We compared the definite TSC groups to identify elements that predict surgical candidacy. Second, we compared all operated patients to assess surgical outcome. Conclusion: We found several factors that could predict a surgical intervention even if identification of patients with refractory epilepsy who can benefit from surgery is an evolving process. Also, several positive factors for good surgical outcome were identified. Patients with the fruste form had excellent surgical outcome.
AB - Aim: The aim of the study was to evaluate the surgical treatment of epilepsy and detection of possible early surgery predictive elements in patients with tuberous sclerosis complex (TSC). Materials and methods: Forty-two TSC patients with epilepsy were selected and divided into two main groups: definite and fruste forms. Definite forms were divided into different groups: patients with pharmacologically controlled epilepsy, patients with pharmacoresistant epilepsy excluded from surgery after an extensive presurgical assessment, and patients with a pharmacoresistant epilepsy who underwent surgery. We compared the definite TSC groups to identify elements that predict surgical candidacy. Second, we compared all operated patients to assess surgical outcome. Conclusion: We found several factors that could predict a surgical intervention even if identification of patients with refractory epilepsy who can benefit from surgery is an evolving process. Also, several positive factors for good surgical outcome were identified. Patients with the fruste form had excellent surgical outcome.
KW - Epilepsy
KW - Surgery
KW - Tuberous sclerosis complex
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U2 - 10.1007/s00381-008-0679-4
DO - 10.1007/s00381-008-0679-4
M3 - Article
C2 - 18704447
AN - SCOPUS:56349099607
VL - 24
SP - 1437
EP - 1445
JO - Child's Nervous System
JF - Child's Nervous System
SN - 0256-7040
IS - 12
ER -