Abstract
Periventricular leukomalacia is the most common type of brain injury in premature infants. Our aim is to describe the frequency and the features of epilepsy in a single-center population of 137 children with periventricular leukomalacia. Forty-two of the 137 (31%) patients presented epilepsy. Twelve percent of these patients presented West syndrome, whereas 19% showed a pattern of continuous spike-waves during slow sleep syndrome. In the latter group, outcome was frequently unfavorable, with a greater number of seizures and more drug resistance. A significant association was found between epilepsy and neonatal seizures, spastic tetraplegia, and mental retardation. Although less common than in other forms of brain injury, epilepsy is nevertheless a significant complication in children with periventricular leukomalacia. The fairly frequent association with continuous spike-waves during slow sleep syndrome deserves particular attention: electroencephalographic sleep monitoring is important in order to provide early treatment and prevent further neurologic deterioration.
| Original language | English |
|---|---|
| Pages (from-to) | 1479-1485 |
| Number of pages | 7 |
| Journal | Journal of Child Neurology |
| Volume | 29 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 8 2014 |
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Keywords
- cerebral palsy
- preterm birth
- sleep-potentiated epileptiform activity
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Medicine(all)
Cite this
Epileptic encephalopathy with continuous spike and wave during sleep associated to periventricular leukomalacia. / De Grandis, Elisa; Mancardi, Maria Margherita; Carelli, Valentina; Carpaneto, Manuela; Morana, Giovanni; Prato, Giulia; Mirabelli-Badenier, Marisol; Pinto, Francesca; Veneselli, Edvige; Baglietto, Maria Giuseppina.
In: Journal of Child Neurology, Vol. 29, No. 11, 08.11.2014, p. 1479-1485.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epileptic encephalopathy with continuous spike and wave during sleep associated to periventricular leukomalacia
AU - De Grandis, Elisa
AU - Mancardi, Maria Margherita
AU - Carelli, Valentina
AU - Carpaneto, Manuela
AU - Morana, Giovanni
AU - Prato, Giulia
AU - Mirabelli-Badenier, Marisol
AU - Pinto, Francesca
AU - Veneselli, Edvige
AU - Baglietto, Maria Giuseppina
PY - 2014/11/8
Y1 - 2014/11/8
N2 - Periventricular leukomalacia is the most common type of brain injury in premature infants. Our aim is to describe the frequency and the features of epilepsy in a single-center population of 137 children with periventricular leukomalacia. Forty-two of the 137 (31%) patients presented epilepsy. Twelve percent of these patients presented West syndrome, whereas 19% showed a pattern of continuous spike-waves during slow sleep syndrome. In the latter group, outcome was frequently unfavorable, with a greater number of seizures and more drug resistance. A significant association was found between epilepsy and neonatal seizures, spastic tetraplegia, and mental retardation. Although less common than in other forms of brain injury, epilepsy is nevertheless a significant complication in children with periventricular leukomalacia. The fairly frequent association with continuous spike-waves during slow sleep syndrome deserves particular attention: electroencephalographic sleep monitoring is important in order to provide early treatment and prevent further neurologic deterioration.
AB - Periventricular leukomalacia is the most common type of brain injury in premature infants. Our aim is to describe the frequency and the features of epilepsy in a single-center population of 137 children with periventricular leukomalacia. Forty-two of the 137 (31%) patients presented epilepsy. Twelve percent of these patients presented West syndrome, whereas 19% showed a pattern of continuous spike-waves during slow sleep syndrome. In the latter group, outcome was frequently unfavorable, with a greater number of seizures and more drug resistance. A significant association was found between epilepsy and neonatal seizures, spastic tetraplegia, and mental retardation. Although less common than in other forms of brain injury, epilepsy is nevertheless a significant complication in children with periventricular leukomalacia. The fairly frequent association with continuous spike-waves during slow sleep syndrome deserves particular attention: electroencephalographic sleep monitoring is important in order to provide early treatment and prevent further neurologic deterioration.
KW - cerebral palsy
KW - preterm birth
KW - sleep-potentiated epileptiform activity
UR - http://www.scopus.com/inward/record.url?scp=84908700830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908700830&partnerID=8YFLogxK
U2 - 10.1177/0883073813508223
DO - 10.1177/0883073813508223
M3 - Article
C2 - 24293309
AN - SCOPUS:84908700830
VL - 29
SP - 1479
EP - 1485
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 11
ER -