Epileptic encephalopathy with continuous spike and wave during sleep associated to periventricular leukomalacia

Elisa De Grandis, Maria Margherita Mancardi, Valentina Carelli, Manuela Carpaneto, Giovanni Morana, Giulia Prato, Marisol Mirabelli-Badenier, Francesca Pinto, Edvige Veneselli, Maria Giuseppina Baglietto

Research output: Contribution to journalArticlepeer-review


Periventricular leukomalacia is the most common type of brain injury in premature infants. Our aim is to describe the frequency and the features of epilepsy in a single-center population of 137 children with periventricular leukomalacia. Forty-two of the 137 (31%) patients presented epilepsy. Twelve percent of these patients presented West syndrome, whereas 19% showed a pattern of continuous spike-waves during slow sleep syndrome. In the latter group, outcome was frequently unfavorable, with a greater number of seizures and more drug resistance. A significant association was found between epilepsy and neonatal seizures, spastic tetraplegia, and mental retardation. Although less common than in other forms of brain injury, epilepsy is nevertheless a significant complication in children with periventricular leukomalacia. The fairly frequent association with continuous spike-waves during slow sleep syndrome deserves particular attention: electroencephalographic sleep monitoring is important in order to provide early treatment and prevent further neurologic deterioration.

Original languageEnglish
Pages (from-to)1479-1485
Number of pages7
JournalJournal of Child Neurology
Issue number11
Publication statusPublished - Nov 8 2014


  • cerebral palsy
  • preterm birth
  • sleep-potentiated epileptiform activity

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


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