Epileptic encephalopathy with continuous spike and wave during sleep associated to periventricular leukomalacia

Elisa De Grandis, Maria Margherita Mancardi, Valentina Carelli, Manuela Carpaneto, Giovanni Morana, Giulia Prato, Marisol Mirabelli-Badenier, Francesca Pinto, Edvige Veneselli, Maria Giuseppina Baglietto

Research output: Contribution to journalArticle

Abstract

Periventricular leukomalacia is the most common type of brain injury in premature infants. Our aim is to describe the frequency and the features of epilepsy in a single-center population of 137 children with periventricular leukomalacia. Forty-two of the 137 (31%) patients presented epilepsy. Twelve percent of these patients presented West syndrome, whereas 19% showed a pattern of continuous spike-waves during slow sleep syndrome. In the latter group, outcome was frequently unfavorable, with a greater number of seizures and more drug resistance. A significant association was found between epilepsy and neonatal seizures, spastic tetraplegia, and mental retardation. Although less common than in other forms of brain injury, epilepsy is nevertheless a significant complication in children with periventricular leukomalacia. The fairly frequent association with continuous spike-waves during slow sleep syndrome deserves particular attention: electroencephalographic sleep monitoring is important in order to provide early treatment and prevent further neurologic deterioration.

Original languageEnglish
Pages (from-to)1479-1485
Number of pages7
JournalJournal of Child Neurology
Volume29
Issue number11
DOIs
Publication statusPublished - Nov 8 2014

Fingerprint

Periventricular Leukomalacia
Brain Diseases
Epilepsy
Sleep
Brain Injuries
Seizures
Infantile Spasms
Quadriplegia
Polysomnography
Drug Resistance
Premature Infants
Intellectual Disability
Nervous System
Population

Keywords

  • cerebral palsy
  • preterm birth
  • sleep-potentiated epileptiform activity

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Epileptic encephalopathy with continuous spike and wave during sleep associated to periventricular leukomalacia. / De Grandis, Elisa; Mancardi, Maria Margherita; Carelli, Valentina; Carpaneto, Manuela; Morana, Giovanni; Prato, Giulia; Mirabelli-Badenier, Marisol; Pinto, Francesca; Veneselli, Edvige; Baglietto, Maria Giuseppina.

In: Journal of Child Neurology, Vol. 29, No. 11, 08.11.2014, p. 1479-1485.

Research output: Contribution to journalArticle

De Grandis, E, Mancardi, MM, Carelli, V, Carpaneto, M, Morana, G, Prato, G, Mirabelli-Badenier, M, Pinto, F, Veneselli, E & Baglietto, MG 2014, 'Epileptic encephalopathy with continuous spike and wave during sleep associated to periventricular leukomalacia', Journal of Child Neurology, vol. 29, no. 11, pp. 1479-1485. https://doi.org/10.1177/0883073813508223
De Grandis, Elisa ; Mancardi, Maria Margherita ; Carelli, Valentina ; Carpaneto, Manuela ; Morana, Giovanni ; Prato, Giulia ; Mirabelli-Badenier, Marisol ; Pinto, Francesca ; Veneselli, Edvige ; Baglietto, Maria Giuseppina. / Epileptic encephalopathy with continuous spike and wave during sleep associated to periventricular leukomalacia. In: Journal of Child Neurology. 2014 ; Vol. 29, No. 11. pp. 1479-1485.
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