Epileptic negative myoclonus in a newborn with hemimegalencephaly

Francesco Guzzetta, Domenica Battaglia, Donatella Lettori, Federica Deodato, Emanuela Sani, Teresa Randò, Daniela Ricci, Celeste Acquafondata, Carmine Faienza

Research output: Contribution to journalArticlepeer-review


Purpose: We report the case of a male newborn with Ohtahara syndrome and right hemimegalencephaly who presented epileptic negative myoclonus in the first days of life. Methods: Prolonged polygraphic studies were performed, as well as MRI and a full clinical examination. Results: EEG showed a constant and nonreactive pattern of burst suppression. There were several kinds of electro-clinical seizures (generalized myoclonia, short atonias, typical spasm and tonic spasms) at the beginning of the EEG's burst. The periods of EMG silence, lasting less than 300 ms, were associated with stereotyped EEG transients. Conclusions: Epileptic negative myoclonus can be observed also in neonatal age. The short transient impairment of motor function observed in the newborn seems linked to the slow component of spike-wave discharge, but its mechanism is still not clear.

Original languageEnglish
Pages (from-to)1106-1109
Number of pages4
Issue number9
Publication statusPublished - Sep 2002


  • Early epileptic encephalopathy
  • Epileptic negative myoclonus
  • Hemimegalencephaly

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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