Epileptogenic Network Formation

Research output: Contribution to journalReview articlepeer-review

Abstract

Epilepsy is characterized by specific alterations in network organization. The main parameters at the basis of epileptogenic network formation are alterations of cortical thickness, development of pathologic hubs, modification of hub distribution, and white matter alterations. The effect is a reinforcement of brain connectivity in both the epileptogenic zone and the propagation zone. Moreover, the epileptogenic network is characterized by some specific neurophysiologic biomarkers that evidence the tendency of the network itself to shift from an interictal state to an ictal one. The recognition of these features is crucial in planning epilepsy surgery.

Original languageEnglish
Pages (from-to)335-344
Number of pages10
JournalNeurosurgery Clinics of North America
Volume31
Issue number3
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Epilepsy surgery
  • Epileptogenesis
  • Epileptogenic network
  • Propagation network

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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