Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment

Chi Un Pae, Antonio Drago, Ashwin A. Patkar, Tae Youn Jun, Alessandro Serretti

Research output: Contribution to journalArticlepeer-review

Abstract

Suggestive associations have been reported between trace amines and heat shock proteins, and a disrupted pathophysiology that enhances the risk of psychosis and that modifies responses to antipsychotic treatments. Our group previously reported genetic studies on TAAR6 and HSP-70 separately in patients with schizophrenia. In the current study, we investigated possible epistasis between the same set of variations in a sample of 281 patients diagnosed with schizophrenia and 288 healthy controls. We applied the generalized multifactor dimensionality reduction (MDR) method and controlled covariates significantly associated with both diagnosis and treatment efficacy. To the best of our knowledge, epistasis between the present set of variations in schizophrenia has not been tested before. We found significant associations with both the risk of disease and response to treatment. However, the insufficiently balanced accuracy of the applied tests suggests that, despite significantly different genetic variations between cases and controls, these factors have a poor predictive value. Explanations for these findings and possible future directions are also discussed.

Original languageEnglish
Pages (from-to)806-811
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume19
Issue number11
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Epistasis
  • Heat shock proteins
  • Response to antipsychotic treatment
  • Schizophrenia
  • Trace amines

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Biological Psychiatry
  • Neurology
  • Pharmacology

Fingerprint Dive into the research topics of 'Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment'. Together they form a unique fingerprint.

Cite this