Epithelial alterations adjacent to 111 vulvar carcinomas

G. Borgno, L. Micheletti, M. Barbero, M. Preti, L. Cavanna, B. Ghiringhello

Research output: Contribution to journalArticlepeer-review


Material from 111 invasive primary vulvar carcinomas was reviewed in order to study the histopathologic changes adjacent to the neoplasia. The histopathologic characteristics of the adjacent tissue were divided into categories. Dystrophic lesions were adjacent to invasive cancer in 57.6% of the cases, carcinoma in situ (CIS) in 21.6% and epithelial changes suggestive of human papillomavirus infection in 18.9%. A spectrum of epithelial changes, ranging from hyperplastic dystrophy without atypia to CIS, was found adjacent to nine cases of invasive carcinoma (8.1%). In 40.5% of the vulvar carcinomas there were no specific alterations surrounding the neoplasia. These data show that dystrophies and CIS were adjacent to invasive carcinomas in nearly 60% and 20% of cases, respectively.

Original languageEnglish
Pages (from-to)500-502
Number of pages3
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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