Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism

Mirco Galiè, Paolo Farace, Cristina Nanni, Antonello Spinelli, Elena Nicolato, Federico Boschi, Paolo Magnani, Silvia Trespidi, Valentina Ambrosini, Stefano Fanti, Flavia Merigo, Francesco Osculati, Pasquina Marzola, Andrea Sbarbati

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Glucose transport and consumption are increased in tumors, and this is considered a diagnostic index of malignancy. However, there is recent evidence that carcinoma-associated stromal cells are capable of aerobic metabolism with low glucose consumption, at least partly because of their efficient vascular supply. In the present study, using dynamic contrast-enhanced magnetic resonance imaging and [F-18]fluorodeoxyglucose (FDG) positron emission tomography (PET), we mapped in vivo the vascular supply and glucose metabolism in syngeneic experimental models of carcinoma and mesenchymal tumor. We found that in both tumor histotypes, regions with high vascular perfusion exhibited a significantly lower FDG uptake. This reciprocity was more conspicuous in carcinomas than in mesenchymal tumors, and regions with a high-vascular/low-FDG uptake pattern roughly overlapped with a stromal capsule and intratumoral large connectival septa. Accordingly, mesenchymal tumors exhibited a higher vascular perfusion and a lower FDG uptake than carcinomas. Thus, we provide in vivo evidence of vascular/metabolic reciprocity between epithelial and mesenchymal histotypes in tumors, suggesting a new intriguing aspect of epithelial-stromal interaction. Our results suggests that FDG-PET-based clinical analysis can underestimate the malignity or tumor extension of carcinomas exhibiting any trait of "mesenchymalization" such as desmoplasia or epithelial-mesenchymal transition.

Original languageEnglish
Pages (from-to)900-908
Number of pages9
JournalNeoplasia (United States)
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 2007

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Blood Vessels
Perfusion
Fluorodeoxyglucose F18
Glucose
Neoplasms
Carcinoma
Positron-Emission Tomography
Epithelial-Mesenchymal Transition
Stromal Cells
Capsules
Theoretical Models
Magnetic Resonance Imaging

Keywords

  • Metabolism
  • MRI
  • PET
  • Tumor
  • Vasculature

ASJC Scopus subject areas

  • Cancer Research

Cite this

Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism. / Galiè, Mirco; Farace, Paolo; Nanni, Cristina; Spinelli, Antonello; Nicolato, Elena; Boschi, Federico; Magnani, Paolo; Trespidi, Silvia; Ambrosini, Valentina; Fanti, Stefano; Merigo, Flavia; Osculati, Francesco; Marzola, Pasquina; Sbarbati, Andrea.

In: Neoplasia (United States), Vol. 9, No. 11, 11.2007, p. 900-908.

Research output: Contribution to journalArticle

Galiè, M, Farace, P, Nanni, C, Spinelli, A, Nicolato, E, Boschi, F, Magnani, P, Trespidi, S, Ambrosini, V, Fanti, S, Merigo, F, Osculati, F, Marzola, P & Sbarbati, A 2007, 'Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism', Neoplasia (United States), vol. 9, no. 11, pp. 900-908. https://doi.org/10.1593/neo.07541
Galiè, Mirco ; Farace, Paolo ; Nanni, Cristina ; Spinelli, Antonello ; Nicolato, Elena ; Boschi, Federico ; Magnani, Paolo ; Trespidi, Silvia ; Ambrosini, Valentina ; Fanti, Stefano ; Merigo, Flavia ; Osculati, Francesco ; Marzola, Pasquina ; Sbarbati, Andrea. / Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism. In: Neoplasia (United States). 2007 ; Vol. 9, No. 11. pp. 900-908.
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