Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance?

Isidro Machado, José A. López-Guerrero, Samuel Navarro, Marco Alberghini, Katia Scotlandi, Piero Picci, Antonio Llombart-Bosch

Research output: Contribution to journalArticlepeer-review

Abstract

Epithelial marker and adhesion molecule expression has been reported in Ewing's sarcoma family of tumors (ESFTs), although the prognostic significance has not been assessed systematically.We performed immunohistochemical analysis of epithelial cell adhesion molecule and epithelial mesenchymal transition markers on 415 genetically confirmed ESFTs. Survival analyses were performed in 217 patients. The atypical histological subtype expressed a high proportion of the epithelial markers compared with conventional and PNET variants. We observed that expression of desmoplakin (p

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalVirchows Archiv
Volume461
Issue number3
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Epithelial markers
  • Ewing's sarcoma
  • Prognostic significance

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance?'. Together they form a unique fingerprint.

Cite this