Epithelial expression of vanilloid and cannabinoid receptors: A potential role in burning mouth syndrome pathogenesis

Elisa Borsani, Alessandra Majorana, Marco Angelo Cocchi, Giulio Conti, Sara Bonadeo, Alessandro Padovani, Giuseppe Lauria, Elena Bardellini, Rita Rezzani, Luigi Fabrizio Rodella

Research output: Contribution to journalArticle

Abstract

Burning mouth syndrome (BMS) is an intraoral burning sensation for which presently no medical or dental causes have been found, and in which the oral mucosa appears normal. It remains an unknown disease for which there is still no long-term treatment. The aim of this study was to assess the epithelial alteration of transient receptor potential vanilloid channel type 1 (TRPV1) and cannabinoid receptors type 1 (CB1) and type 2 (CB2) in the human tongue. The study was performed on eight healthy controls and eight BMS patients. All patients underwent a 3-mm punch biopsy at the anterolateral aspect of the tongue close to the tip. TRPV1, CB1 and CB2 immunohistochemistry was carried out showing an altered expression of all receptors. In BMS patients there was increased TRPV1, decreased CB1 and increased CB2 expression in tongue epithelial cells also associated with a change in their distribution. It would appear that these receptors are related to BMS. These data could be useful for future characterization of BMS epithelial markers and therapy.

Original languageEnglish
Pages (from-to)523-533
Number of pages11
JournalHistology and Histopathology
Volume29
Issue number4
Publication statusPublished - 2014

Fingerprint

Burning Mouth Syndrome
TRPV Cation Channels
Cannabinoid Receptors
Transient Receptor Potential Channels
Tongue
Cannabinoid Receptor CB1
Mouth Mucosa
Tooth
Epithelial Cells
Immunohistochemistry
Biopsy
Therapeutics

Keywords

  • Burning mouth syndrome
  • Cannabinoid receptor type 1
  • Cannabinoid receptor type 2
  • Human tongue
  • Transient receptor potential vanilloid channel type 1

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Borsani, E., Majorana, A., Cocchi, M. A., Conti, G., Bonadeo, S., Padovani, A., ... Rodella, L. F. (2014). Epithelial expression of vanilloid and cannabinoid receptors: A potential role in burning mouth syndrome pathogenesis. Histology and Histopathology, 29(4), 523-533.

Epithelial expression of vanilloid and cannabinoid receptors : A potential role in burning mouth syndrome pathogenesis. / Borsani, Elisa; Majorana, Alessandra; Cocchi, Marco Angelo; Conti, Giulio; Bonadeo, Sara; Padovani, Alessandro; Lauria, Giuseppe; Bardellini, Elena; Rezzani, Rita; Rodella, Luigi Fabrizio.

In: Histology and Histopathology, Vol. 29, No. 4, 2014, p. 523-533.

Research output: Contribution to journalArticle

Borsani, E, Majorana, A, Cocchi, MA, Conti, G, Bonadeo, S, Padovani, A, Lauria, G, Bardellini, E, Rezzani, R & Rodella, LF 2014, 'Epithelial expression of vanilloid and cannabinoid receptors: A potential role in burning mouth syndrome pathogenesis', Histology and Histopathology, vol. 29, no. 4, pp. 523-533.
Borsani, Elisa ; Majorana, Alessandra ; Cocchi, Marco Angelo ; Conti, Giulio ; Bonadeo, Sara ; Padovani, Alessandro ; Lauria, Giuseppe ; Bardellini, Elena ; Rezzani, Rita ; Rodella, Luigi Fabrizio. / Epithelial expression of vanilloid and cannabinoid receptors : A potential role in burning mouth syndrome pathogenesis. In: Histology and Histopathology. 2014 ; Vol. 29, No. 4. pp. 523-533.
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