TY - JOUR
T1 - Epithelial-mesenchymal interactions
T2 - A fundamental developmental biology mechanism
AU - Ribatti, Domenico
AU - Santoiemma, Marcello
PY - 2014
Y1 - 2014
N2 - Interactions between epithelium and mesenchyme are common features of early stages of morphogenesis in different organs. In this historical review article, we retrospectively analyze the most important contribution to the definition and characterization of these interactions in three different organogenetic systems, including kidney, lung and limb bud. Tubule formation in the kidney is an example of an organogenetic event which involves interaction between the ureteric epithelium and the underlying mesenchyme that, in turn, induces the branching of the ureteric epithelium. In contrast, in lung organogenesis, interactive signaling occurs between the endodermal epithelium and the mesenchyme, leading to an alveolar structure. Finally, limb bud development results from a series of epithelial-mesenchymal interactions between the mesenchymal cells of the lateral plate mesoderm and the overlying ectodermal cells.
AB - Interactions between epithelium and mesenchyme are common features of early stages of morphogenesis in different organs. In this historical review article, we retrospectively analyze the most important contribution to the definition and characterization of these interactions in three different organogenetic systems, including kidney, lung and limb bud. Tubule formation in the kidney is an example of an organogenetic event which involves interaction between the ureteric epithelium and the underlying mesenchyme that, in turn, induces the branching of the ureteric epithelium. In contrast, in lung organogenesis, interactive signaling occurs between the endodermal epithelium and the mesenchyme, leading to an alveolar structure. Finally, limb bud development results from a series of epithelial-mesenchymal interactions between the mesenchymal cells of the lateral plate mesoderm and the overlying ectodermal cells.
KW - Embryology
KW - Epithelia
KW - Kidney
KW - Limb bud
KW - Lung
KW - Mesenchyme
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U2 - 10.1387/ijdb.140143dr
DO - 10.1387/ijdb.140143dr
M3 - Article
C2 - 25354449
AN - SCOPUS:84908103658
VL - 58
SP - 303
EP - 306
JO - International Journal of Developmental Biology
JF - International Journal of Developmental Biology
SN - 0214-6282
IS - 5
ER -