Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma

Claudia Casarsa, Niccolò Bassani, Federico Ambrogi, Giuliano Zabucchi, Patrizia Boracchi, Elia Biganzoli, Danila Coradini

Research output: Contribution to journalArticle

Abstract

Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and stemness features. The association between MPM histologies and genes expression were explored using active and passive Principal Components Analysis-based biplots and PAM analysis that provided evidence that with respect to normal tissues, MPMs histologies were better characterized by specific patterns of expression of genes involved in EMT activation, cell polarity and stemness.

Original languageEnglish
Pages (from-to)136-143
Number of pages8
JournalCancer Letters
Volume302
Issue number2
DOIs
Publication statusPublished - Mar 28 2011

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Keywords

  • Cell polarity
  • Epithelial-to-mesenchymal transition
  • Malignant pleural mesothelioma
  • Stemness features

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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