Epithelial Tumors of the Ovary in Children and Teenagers: A Prospective Study from the Italian TREP Project

Calogero Virgone, Rita Alaggio, Patrizia Dall'Igna, Piero Buffa, Luca Tonegatti, Andrea Ferrari, Gianni Bisogno, Giovanni Cecchetto

Research output: Contribution to journalArticlepeer-review


Study Objective: To report the clinical findings and treatment results of a series of patients with epithelial tumors of the ovary, registered and treated prospectively in a multi-institutional Italian network (TREP project) on rare tumors in children and adolescent between 2000 and 2014. Design, Setting, and Participants: Data on 16 patients, aged 22 to 206 months, from 7 centers were reviewed. All patients were grouped on the basis of the results of the first surgical approach, according to the Children Oncology Group staging system. Results: The most frequent symptom was abdominal pain; 3 patients were hospitalized for acute pain after ovarian torsion. Initial surgical treatment was complete in 15 of 16, and a biopsy was performed in 1 of 16. The histology examination revealed 8 benign tumors (7 mucinous cystadenomas and 1 serous cystadenoma) and 8 borderline tumors (2 serous and 6 mucinous). Fifteen of 16 patients maintained the complete remission after surgical treatment alone; 1 affected by Proteus syndrome died consequent to the progression of a synchronous Wilms tumor, after a delayed incomplete surgery. Conclusion: Our analysis documented the rarity of these tumors in children and adolescents. No malignant histologies were found. Surgery alone was effective to cure the majority of patients. Considering the rarity of malignant entities, ovary-sparing surgery may be planned when an epithelial tumor is suspected on the basis of the preoperative work-up and intraoperative findings.

Original languageEnglish
Pages (from-to)441-446
Number of pages6
JournalJournal of Pediatric and Adolescent Gynecology
Issue number6
Publication statusPublished - Dec 1 2015


  • Borderline ovarian tumors
  • Epithelial ovarian tumors
  • Mucinous cystadenoma
  • Pediatric ovarian tumors
  • Serous cystadenoma

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health


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