Epithelioid sarcoma involving the skin. A histopathological and immunohistochemical study of four cases

Raffaele Gianotti, Antonina Parafioriti, Lucia Restano, Elvio Alessi

Research output: Contribution to journalArticle

Abstract

We studied the histological and immunohistochemical features of four cases of epithelioid sarcoma (ES)-presenting at the onset as inflammatory disease. Two patients were females having subcutaneous nodules located on the wrist and arm. The other two patients had multiple nodules running from the palm to the elbow. Histopathology showed neoplastic cells disposed in a large nodular pattern or small multiple granulematous-like foci. The constituent cellular elements ranged from large ovoid or polygonal cells with deeply eosinophilic cytoplasm to spindle cells. Immunohistochemical study demonstrated in all the cases the expression of vimentin, AE1/AE3 cytokeratin, CAM 5.2, and EMA. S100 was negative. We suggest that the original hypothesis, that ES originates from a primitive, undifferentiated, mesenchymal cell, resident in the dermis with the ability to differentiate along different cell lines, is actually the most probable.

Original languageEnglish
Pages (from-to)347-349
Number of pages3
JournalEuropean Journal of Dermatology
Volume6
Issue number5
Publication statusPublished - 1996

Keywords

  • Epithelioid sarcoma
  • Immunohistochemistry
  • Sarcoma

ASJC Scopus subject areas

  • Dermatology

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