Epithelioma of Malherbe: New ultrasound patterns

Francesco M. Solivetti, Fulvia Elia, Alessandra Drusco, Chiara Panetta, Ada Amantea, Aldo Di Carlo

Research output: Contribution to journalArticlepeer-review


Background: Calcifying epithelioma of Malherbe, or Pilomatricoma, is considered an uncommon cutaneous neoplasia, normally occurring in children as a solitary, firm, asymptomatic, hard, subcutaneous, slowly growing nodule on the face, neck, or proximal upper extremity. In literature, two Pilomatricoma ultrasound patterns are described: the totally calcified nodule and the hypoechoic nodule with internal calcific foci.High frequency ultrasound has not yet been applied for routine diagnosis of Pilomatricoma.The aim of the study was to retrospectively identify specific ultrasound features. Methods: We retrieved 124 histologically Pilomatricoma cases: 28 patients with 32 lesions were preoperatively evaluated with ultrasound. Results: 22/32 have shown a solid formation, hypoechoic, with a sharp outline. Of these 22, 10 lesions were completely calcifying and 12 partially calcified. In 3/32 lesions with uncertain diagnosis, ultrasounds showed a complex/mixed pattern with pseudo-fluid areas and microspots. 7/32 lesions with US different diagnosis included 3 complex lesions, 2 cystic lesions and 2 solid nodular lesions. Conclusion: In addition to well-known ultrasound patterns (completely calcified and partially calcified) we identified three new, not yet described, patterns that constitute the 31% of the cases: complex, pseudocistyc and pseudotumoral.

Original languageEnglish
Pages (from-to)42
Number of pages1
JournalJournal of Experimental and Clinical Cancer Research
Publication statusAccepted/In press - May 6 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)


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