TY - JOUR
T1 - Impiego di eritropoietina alfa nei programmi di chemioterapia ad alte dosi
AU - Danova, Marco
AU - Aglietta, Massimo
AU - Pierelli, Luca
AU - Ferrari, Silvia
AU - Perillo, Alessandro
AU - Scambia, Giovanni
AU - Henry, David
PY - 2000/12
Y1 - 2000/12
N2 - Epoetin (Epo) is physiologically present in the human body, stimulating erythropoiesis from bone marrow. Anemia is observed in cancer patients submitted to high-dose chemotherapy (HDCT), mainly caused by myelosuppression. Epoetin alfa has been widely used to treat the anemia that develops in the HDCT setting. Controlled studies in patients with hematologic malignancies or solid tumors who received Epo following HDCT have shown a decreased red blood cell transfusion requirement at least in patients receiving allogeneic bone marrow transplantation (BMT), while results in patients receiving autologous BMT have been disappointing. The administration of Epo before HDCT, in a period when bone marrow is still responsive to growth factors, may represent a new strategy aimed at decreasing the degree of anemia in these patients. A combination of granulocyte-colony stimulating factor and Epo has proved to be effective in mobilizing stem cell and committed myelold/erythroid precursors.
AB - Epoetin (Epo) is physiologically present in the human body, stimulating erythropoiesis from bone marrow. Anemia is observed in cancer patients submitted to high-dose chemotherapy (HDCT), mainly caused by myelosuppression. Epoetin alfa has been widely used to treat the anemia that develops in the HDCT setting. Controlled studies in patients with hematologic malignancies or solid tumors who received Epo following HDCT have shown a decreased red blood cell transfusion requirement at least in patients receiving allogeneic bone marrow transplantation (BMT), while results in patients receiving autologous BMT have been disappointing. The administration of Epo before HDCT, in a period when bone marrow is still responsive to growth factors, may represent a new strategy aimed at decreasing the degree of anemia in these patients. A combination of granulocyte-colony stimulating factor and Epo has proved to be effective in mobilizing stem cell and committed myelold/erythroid precursors.
KW - Autologous and allogeneic bone arrow transplantation
KW - Circulating progenitor cell mobilization
KW - Erythropoietin
KW - High-dose chemotherapy
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M3 - Articolo
C2 - 11194490
AN - SCOPUS:0034533847
VL - 91
SP - 681
EP - 689
JO - Recenti Progressi in Medicina
JF - Recenti Progressi in Medicina
SN - 0034-1193
IS - 12
ER -