Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis

V. Nociti, G. Frisullo, A. Marti, M. Luigetti, R. Iorio, A. K. Patanella, A. Bianco, P. A. Tonali, R. L. Grillo, M. Sabatelli, A. P. Batocchi

Research output: Contribution to journalArticle

Abstract

Elevated anti-Epstein-Barr virus (EBV) antibody levels are present in serum of Multiple sclerosis (MS) patients but literature lacks of studies comparing anti-EBV antibody levels between MS and other neurological diseases. We evaluate anti-VCA IgG and IgM, anti-EBNA1 IgG, anti-Cytomegalovirus IgG and IgM titres in serum and cerebrospinal fluid (CSF) of 267 MS, 50 Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) and 88 Amyotrophic Lateral Sclerosis (ALS) patients. We found increased titres of anti-EBV-IgG in serum and CSF of MS subjects as compared to CIDP and ALS patients thus providing additional evidence for a possible involvement of EBV in MS.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalJournal of Neuroimmunology
Volume225
Issue number1-2
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Amyotrophic Lateral Sclerosis
  • Chronic Inflammatory Demyelinating Polyradiculoneuropathy
  • Cytomegalovirus
  • Epstein-Barr virus
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Fingerprint Dive into the research topics of 'Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis'. Together they form a unique fingerprint.

  • Cite this