Epstein-Barr virus-associated lymphoma in Crohn's disease

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Although no increased risk of developing lymphoproliferative disorders has been observed in population-based studies of patients with Crohn's disease, the possibility has been suggested in the subset of patients previously treated with thiopurine metabolites and suffering from concomitant Epstein-Barr virus infection. A few cases of lymphomas have occurred in patients with Crohn's disease treated with infliximab, only one of whom showed the presence of the Epstein-Barr virus genome. We here describe the case of a patient with steroid-dependent ileal Crohn's disease treated with azathioprine and a single infusion of infliximab, who developed a diffuse large B cell ileal lymphoma. Epstein-Barr virus genome was detected in the neoplastic cells by means of polymerase chain reaction. Epstein-Barr virus may be detected in the neoplastic tissues of lymphomas of patients with Crohn's disease treated with immunosuppressants and infliximab. The identification of such cases may help to define the frequency of this association and how to manage the lymphoproliferative disorder.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalInflammatory Bowel Diseases
Volume10
Issue number4
DOIs
Publication statusPublished - Jul 2004

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Human Herpesvirus 4
Crohn Disease
Lymphoma
Lymphoproliferative Disorders
Ileal Diseases
Genome
Epstein-Barr Virus Infections
Lymphoma, Large B-Cell, Diffuse
Azathioprine
Immunosuppressive Agents
Steroids
Polymerase Chain Reaction
Population
Infliximab

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Epstein-Barr virus-associated lymphoma in Crohn's disease. / Losco, Alessandra; Gianelli, Umberto; Cassani, Barbara; Baldini, Luca; Conte, Dario; Basilisco, Guido.

In: Inflammatory Bowel Diseases, Vol. 10, No. 4, 07.2004, p. 425-429.

Research output: Contribution to journalArticle

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