Abstract
Although no increased risk of developing lymphoproliferative disorders has been observed in population-based studies of patients with Crohn's disease, the possibility has been suggested in the subset of patients previously treated with thiopurine metabolites and suffering from concomitant Epstein-Barr virus infection. A few cases of lymphomas have occurred in patients with Crohn's disease treated with infliximab, only one of whom showed the presence of the Epstein-Barr virus genome. We here describe the case of a patient with steroid-dependent ileal Crohn's disease treated with azathioprine and a single infusion of infliximab, who developed a diffuse large B cell ileal lymphoma. Epstein-Barr virus genome was detected in the neoplastic cells by means of polymerase chain reaction. Epstein-Barr virus may be detected in the neoplastic tissues of lymphomas of patients with Crohn's disease treated with immunosuppressants and infliximab. The identification of such cases may help to define the frequency of this association and how to manage the lymphoproliferative disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 425-429 |
| Number of pages | 5 |
| Journal | Inflammatory Bowel Diseases |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2004 |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Epstein-Barr virus-associated lymphoma in Crohn's disease. / Losco, Alessandra; Gianelli, Umberto; Cassani, Barbara; Baldini, Luca; Conte, Dario; Basilisco, Guido.
In: Inflammatory Bowel Diseases, Vol. 10, No. 4, 07.2004, p. 425-429.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epstein-Barr virus-associated lymphoma in Crohn's disease
AU - Losco, Alessandra
AU - Gianelli, Umberto
AU - Cassani, Barbara
AU - Baldini, Luca
AU - Conte, Dario
AU - Basilisco, Guido
PY - 2004/7
Y1 - 2004/7
N2 - Although no increased risk of developing lymphoproliferative disorders has been observed in population-based studies of patients with Crohn's disease, the possibility has been suggested in the subset of patients previously treated with thiopurine metabolites and suffering from concomitant Epstein-Barr virus infection. A few cases of lymphomas have occurred in patients with Crohn's disease treated with infliximab, only one of whom showed the presence of the Epstein-Barr virus genome. We here describe the case of a patient with steroid-dependent ileal Crohn's disease treated with azathioprine and a single infusion of infliximab, who developed a diffuse large B cell ileal lymphoma. Epstein-Barr virus genome was detected in the neoplastic cells by means of polymerase chain reaction. Epstein-Barr virus may be detected in the neoplastic tissues of lymphomas of patients with Crohn's disease treated with immunosuppressants and infliximab. The identification of such cases may help to define the frequency of this association and how to manage the lymphoproliferative disorder.
AB - Although no increased risk of developing lymphoproliferative disorders has been observed in population-based studies of patients with Crohn's disease, the possibility has been suggested in the subset of patients previously treated with thiopurine metabolites and suffering from concomitant Epstein-Barr virus infection. A few cases of lymphomas have occurred in patients with Crohn's disease treated with infliximab, only one of whom showed the presence of the Epstein-Barr virus genome. We here describe the case of a patient with steroid-dependent ileal Crohn's disease treated with azathioprine and a single infusion of infliximab, who developed a diffuse large B cell ileal lymphoma. Epstein-Barr virus genome was detected in the neoplastic cells by means of polymerase chain reaction. Epstein-Barr virus may be detected in the neoplastic tissues of lymphomas of patients with Crohn's disease treated with immunosuppressants and infliximab. The identification of such cases may help to define the frequency of this association and how to manage the lymphoproliferative disorder.
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U2 - 10.1097/00054725-200407000-00015
DO - 10.1097/00054725-200407000-00015
M3 - Article
VL - 10
SP - 425
EP - 429
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
SN - 1078-0998
IS - 4
ER -