TY - JOUR
T1 - Epstein-Barr virus BART microRNAs in EBV- associated Hodgkin lymphoma and gastric cancer
AU - De Re, Valli
AU - Caggiari, Laura
AU - De Zorzi, Mariangela
AU - Fanotto, Valentina
AU - Miolo, Gianmaria
AU - Puglisi, Fabio
AU - Puglisi, Fabio
AU - Cannizzaro, Renato
AU - Cannizzaro, Renato
AU - Canzonieri, Vincenzo
AU - Steffan, Agostino
AU - Farruggia, Piero
AU - Lopci, Egesta
AU - D'amore, Emanuele S.G.
AU - Burnelli, Roberta
AU - Mussolin, Lara
AU - Mascarin, Maurizio
N1 - Publisher Copyright:
© 2020 The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/23
Y1 - 2020/6/23
N2 - Background: EBV produces miRNAs with important functions in cancer growth, tumor invasion and host immune surveillance. The discovery of EBV miR-BARTs is recent, and most of their functions are still unknown. Nonetheless, some new studies underline their key roles in EBV-associated malignancies. Main body: In EBV-associated tumors, the expression profile of miR-BARTs varies according to the cell type, autophagic process and signals received from the tumor microenvironment. By the same way of interest is the interaction between tumor cells and the tumor environment by the release of selected EBV miR-BARTs in addition to the tumor proteins trough tumor exosomes. Conclusion: In this review, we discuss new findings regarding EBV miR-BARTs in Hodgkin lymphoma and gastric cancer. The recent discovery that miRNAs are released by exosomes, including miR-BARTs, highlights the importance of tumor and microenvironment interplay with more specific effects on the host immune response.
AB - Background: EBV produces miRNAs with important functions in cancer growth, tumor invasion and host immune surveillance. The discovery of EBV miR-BARTs is recent, and most of their functions are still unknown. Nonetheless, some new studies underline their key roles in EBV-associated malignancies. Main body: In EBV-associated tumors, the expression profile of miR-BARTs varies according to the cell type, autophagic process and signals received from the tumor microenvironment. By the same way of interest is the interaction between tumor cells and the tumor environment by the release of selected EBV miR-BARTs in addition to the tumor proteins trough tumor exosomes. Conclusion: In this review, we discuss new findings regarding EBV miR-BARTs in Hodgkin lymphoma and gastric cancer. The recent discovery that miRNAs are released by exosomes, including miR-BARTs, highlights the importance of tumor and microenvironment interplay with more specific effects on the host immune response.
KW - BamHI fragment a rightward transcript
KW - EBV
KW - Epstein-Barr virus; miRNA
KW - Gastric carcinoma cancer
KW - HL
KW - Hodgkin lymphoma; GC
KW - Micro RNA; BART
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U2 - 10.1186/s13027-020-00307-6
DO - 10.1186/s13027-020-00307-6
M3 - Review article
AN - SCOPUS:85087817360
VL - 15
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
SN - 1750-9378
IS - 1
M1 - 42
ER -