Epstein-Barr virus

Induction and control of cell transformation

Riccardo Dolcetti, Maria G. Masucci

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV), a ubiquitous human herpes virus, is associated with an increasing number of lymphoid and epithelial malignancies. The ability of the virus to establish life-long persistent infections and induce growth transformation is related to the function of a set of viral proteins that are variously expressed in both normal and malignant cells. Recent evidence indicates that these viral proteins are able to usurp cellular pathways that promote the cell growth and survival, while impairing anti-viral immune responses. Elucidation of the mechanisms by which EBV induces cell transformation and escapes host immune control provides the rational background for the design of new strategies of intervention for EBV-related malignancies.

Original languageEnglish
Pages (from-to)207-218
Number of pages12
JournalJournal of Cellular Physiology
Volume196
Issue number2
DOIs
Publication statusPublished - Aug 1 2003

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Virus Activation
Human Herpesvirus 4
Viruses
Viral Proteins
Growth
Neoplasms
Cell Survival
Cell growth
Infection

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

Cite this

Epstein-Barr virus : Induction and control of cell transformation. / Dolcetti, Riccardo; Masucci, Maria G.

In: Journal of Cellular Physiology, Vol. 196, No. 2, 01.08.2003, p. 207-218.

Research output: Contribution to journalArticle

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