Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors

M. Cirone, A. Angeloni, G. Barile, C. Zompetta, M. Venenzoni, M. R. Torrisi, L. Frati, A. Faggioni

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Selective protein kinase C inhibitors can either block or significantly reduce Epstein-Barr virus infectivity: inhibition of transformation and decreased 3H-thymidine (3H-TdR) incorporation in human B lymphocytes infected with B95-8 EBV, as well as a signficant reduction in the induction of early antigens in Raji cells superinfected by P3HR1 EBV was achieved by pre-treating the cells with the inhibitors. The inhibitors do not act by blocking binding of the virus to its cellular receptor CR 2, but rather are effective in the viral internalization process. Our results suggest that protein kinase C may be involved in the process of viral entry into cells.

Original languageEnglish
Pages (from-to)490-493
Number of pages4
JournalInternational Journal of Cancer
Volume45
Issue number3
Publication statusPublished - 1990

Fingerprint

Virus Internalization
Protein C Inhibitor
Protein Kinase Inhibitors
Human Herpesvirus 4
Protein Kinase C
Virus Attachment
Thymidine
B-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cirone, M., Angeloni, A., Barile, G., Zompetta, C., Venenzoni, M., Torrisi, M. R., ... Faggioni, A. (1990). Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors. International Journal of Cancer, 45(3), 490-493.

Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors. / Cirone, M.; Angeloni, A.; Barile, G.; Zompetta, C.; Venenzoni, M.; Torrisi, M. R.; Frati, L.; Faggioni, A.

In: International Journal of Cancer, Vol. 45, No. 3, 1990, p. 490-493.

Research output: Contribution to journalArticle

Cirone, M, Angeloni, A, Barile, G, Zompetta, C, Venenzoni, M, Torrisi, MR, Frati, L & Faggioni, A 1990, 'Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors', International Journal of Cancer, vol. 45, no. 3, pp. 490-493.
Cirone M, Angeloni A, Barile G, Zompetta C, Venenzoni M, Torrisi MR et al. Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors. International Journal of Cancer. 1990;45(3):490-493.
Cirone, M. ; Angeloni, A. ; Barile, G. ; Zompetta, C. ; Venenzoni, M. ; Torrisi, M. R. ; Frati, L. ; Faggioni, A. / Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors. In: International Journal of Cancer. 1990 ; Vol. 45, No. 3. pp. 490-493.
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