Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis

R. Zivadinov, M. Zorzon, B. Weinstock-Guttman, M. Serafin, A. Bosco, A. Bratina, C. Maggiore, A. Grop, M. A. Tommasi, B. Srinivasaraghavan, M. Ramanathan

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of the study was to determine whether the presence of anti-Epstein-Barr virus (EBV) antibodies is associated with MRI measures of brain injury and neurodegeneration in patients with multiple sclerosis (MS). Methods: 135 patients with MS (86 women, 49 men) underwent brain MRI and testing for antibodies against EBV. MRI measurements included gadolinium enhancing lesion volume, T1 and T2 lesion volumes and fractions of whole brain parenchyma (BPF), white matter and grey matter (GMF). The anti-EBV panel included anti-EBV early antigen IgG, anti-EBV nuclear antigen IgG and anti-EBV viral capsid antigen (VCA) IgG levels. The relationships between antibody levels and MRI measurements were assessed in regression analysis. Repeat measurements of anti-EBV VCA IgG and MRI measures were available for a subset of 50 patients after a mean follow-up of 3.1 years. Results: GMF (R2 = 0.24 for overall model, p = 0.002) and BPF (R2 = 0.39 for overall model, p

Original languageEnglish
Pages (from-to)620-625
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume80
Issue number6
DOIs
Publication statusPublished - Jun 2009

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Human Herpesvirus 4
Multiple Sclerosis
Atrophy
Glia Maturation Factor
Antibodies
Immunoglobulin G
Epstein-Barr Virus Nuclear Antigens
Gadolinium
Brain
Brain Injuries
Regression Analysis
Gray Matter
anti-IgG
Epstein-Barr viral capsid antigen

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Medicine(all)

Cite this

Zivadinov, R., Zorzon, M., Weinstock-Guttman, B., Serafin, M., Bosco, A., Bratina, A., ... Ramanathan, M. (2009). Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 80(6), 620-625. https://doi.org/10.1136/jnnp.2008.154906

Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis. / Zivadinov, R.; Zorzon, M.; Weinstock-Guttman, B.; Serafin, M.; Bosco, A.; Bratina, A.; Maggiore, C.; Grop, A.; Tommasi, M. A.; Srinivasaraghavan, B.; Ramanathan, M.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 80, No. 6, 06.2009, p. 620-625.

Research output: Contribution to journalArticle

Zivadinov, R, Zorzon, M, Weinstock-Guttman, B, Serafin, M, Bosco, A, Bratina, A, Maggiore, C, Grop, A, Tommasi, MA, Srinivasaraghavan, B & Ramanathan, M 2009, 'Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis', Journal of Neurology, Neurosurgery and Psychiatry, vol. 80, no. 6, pp. 620-625. https://doi.org/10.1136/jnnp.2008.154906
Zivadinov, R. ; Zorzon, M. ; Weinstock-Guttman, B. ; Serafin, M. ; Bosco, A. ; Bratina, A. ; Maggiore, C. ; Grop, A. ; Tommasi, M. A. ; Srinivasaraghavan, B. ; Ramanathan, M. / Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis. In: Journal of Neurology, Neurosurgery and Psychiatry. 2009 ; Vol. 80, No. 6. pp. 620-625.
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