Epstein-Barr virus-positive aggressive lymphoma as a consequence of immunosuppression after multiple salvage treatments for follicular lymphoma

Ester Orlandi, Marco Paulli, Alessandra Viglio, Guido Pagnucco, Roberta Riboni, Fausto Baldanti, Mario Lazzarino

Research output: Contribution to journalArticlepeer-review

Abstract

We report on a patient with follicular non-Hodgkin's lymphoma (NHL) who developed a fatal high-grade Epstein-Barr virus (EBV)-positive NHL after conventional chemotherapies. The sudden onset of the high-grade lymphoma was accompanied by increasing circulating EBV genome copies and was complicated by spontaneous rupture of the spleen. Splenic tissue was diffusely infiltrated by large B cells. In situ hybridization for Epstein-Barr-encoded RNA (EBER) 1-2 was positive in 70% of cells, and molecular analysis revealed the presence of EBV DNA and a monoclonal IgH gene rearrangement. This case shows that the immunosuppression of multiple treatments may induce uncontrolled reactivation of a latent EBV infection, contributing to high-grade transformation in heavily treated lymphoma patients.

Original languageEnglish
Pages (from-to)373-376
Number of pages4
JournalBritish Journal of Haematology
Volume112
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Chemotherapy
  • EBV-positive lymphoma
  • Immunosuppression

ASJC Scopus subject areas

  • Hematology

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