Epstein-Barr virus serology in nasopharyngeal carcinomas and other head and neck neoplasms in Italy

A. Faggioni, C. Corradini, G. Barile, G. Cardi, V. Ciarniello, M. Venenzoni, C. Zompetta, M. Maurizi, G. Paludetti, V. Manzari, A. Gradilone, L. Frati

Research output: Contribution to journalArticlepeer-review

Abstract

This paper reports the results of the EBV-specific antibody response in 17 Italian nasopharyngeal carcinoma (NPC) patients, 15 other head and neck tumor patients and 15 normal controls. Nucleic acid hybridization has been performed on the biopsy tissue from 4 of the NPC patients, and EBV-DNA was present in two undifferentiated (WHO 3) tumors, and absent in two samples of the keratinizing (WHO 1) type. EBV serology appears to be specifically related to NPC, more evidently for VCA-IgA and EA-IgG antibodies, and useful as an aid in diagnosis of NPC. However, in order to assess a prognostic value of the above markers, a greater number of patients followed for a longer period of time (at least 5 years) is needed, and is currently being pursued.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalJournal of Cancer Research and Clinical Oncology
Volume110
Issue number2
DOIs
Publication statusPublished - Sep 1985

Keywords

  • Antibodies
  • Epstein-Barr virus
  • Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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