Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies

Massimiliano Castellazzi, Carlo Contini, Carmine Tamborino, Francesca Fasolo, Gloria Roversi, Silva Seraceni, Roberta Rizzo, Eleonora Baldi, Maria Rosaria Tola, Tiziana Bellini, Enrico Granieri, Enrico Fainardi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The purpose of this study was to investigate intrathecal production and affinity distributions of Epstein-Barr virus (EBV)-specific antibodies in multiple sclerosis (MS) and controls. Methods: Cerebrospinal fluid (CSF) and serum concentrations, quantitative intrathecal synthesis, oligoclonal bands (OCB) patterns and affinity distributions of anti-Epstein Barr virus (EBV) antibodies were evaluated in 100 relapsing-remitting MS (RRMS) patients and 200 age- and sex-matched controls with other inflammatory neurological disorders (OIND) and other noninflammatory neurological disorders (NIND). Results: Levels of anti-EBNA-1 and anti-viral capsid antigen (VCA) IgG were different in both the CSF (P

Original languageEnglish
Pages (from-to)188
Number of pages1
JournalJournal of Neuroinflammation
DOIs
Publication statusAccepted/In press - Nov 13 2014

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Oligoclonal Bands
Relapsing-Remitting Multiple Sclerosis
Antibody Affinity
Nervous System Diseases
Human Herpesvirus 4
Cerebrospinal Fluid
Viral Antigens
Antibodies
Capsid
Multiple Sclerosis
Immunoglobulin G
Serum
EBV-encoded nuclear antigen 1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Neurology
  • Immunology

Cite this

Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies. / Castellazzi, Massimiliano; Contini, Carlo; Tamborino, Carmine; Fasolo, Francesca; Roversi, Gloria; Seraceni, Silva; Rizzo, Roberta; Baldi, Eleonora; Tola, Maria Rosaria; Bellini, Tiziana; Granieri, Enrico; Fainardi, Enrico.

In: Journal of Neuroinflammation, 13.11.2014, p. 188.

Research output: Contribution to journalArticle

Castellazzi, Massimiliano ; Contini, Carlo ; Tamborino, Carmine ; Fasolo, Francesca ; Roversi, Gloria ; Seraceni, Silva ; Rizzo, Roberta ; Baldi, Eleonora ; Tola, Maria Rosaria ; Bellini, Tiziana ; Granieri, Enrico ; Fainardi, Enrico. / Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies. In: Journal of Neuroinflammation. 2014 ; pp. 188.
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abstract = "Background: The purpose of this study was to investigate intrathecal production and affinity distributions of Epstein-Barr virus (EBV)-specific antibodies in multiple sclerosis (MS) and controls. Methods: Cerebrospinal fluid (CSF) and serum concentrations, quantitative intrathecal synthesis, oligoclonal bands (OCB) patterns and affinity distributions of anti-Epstein Barr virus (EBV) antibodies were evaluated in 100 relapsing-remitting MS (RRMS) patients and 200 age- and sex-matched controls with other inflammatory neurological disorders (OIND) and other noninflammatory neurological disorders (NIND). Results: Levels of anti-EBNA-1 and anti-viral capsid antigen (VCA) IgG were different in both the CSF (P",
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AU - Castellazzi, Massimiliano

AU - Contini, Carlo

AU - Tamborino, Carmine

AU - Fasolo, Francesca

AU - Roversi, Gloria

AU - Seraceni, Silva

AU - Rizzo, Roberta

AU - Baldi, Eleonora

AU - Tola, Maria Rosaria

AU - Bellini, Tiziana

AU - Granieri, Enrico

AU - Fainardi, Enrico

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AB - Background: The purpose of this study was to investigate intrathecal production and affinity distributions of Epstein-Barr virus (EBV)-specific antibodies in multiple sclerosis (MS) and controls. Methods: Cerebrospinal fluid (CSF) and serum concentrations, quantitative intrathecal synthesis, oligoclonal bands (OCB) patterns and affinity distributions of anti-Epstein Barr virus (EBV) antibodies were evaluated in 100 relapsing-remitting MS (RRMS) patients and 200 age- and sex-matched controls with other inflammatory neurological disorders (OIND) and other noninflammatory neurological disorders (NIND). Results: Levels of anti-EBNA-1 and anti-viral capsid antigen (VCA) IgG were different in both the CSF (P

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