Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies

Massimiliano Castellazzi, Carlo Contini, Carmine Tamborino, Francesca Fasolo, Gloria Roversi, Silva Seraceni, Roberta Rizzo, Eleonora Baldi, Maria Rosaria Tola, Tiziana Bellini, Enrico Granieri, Enrico Fainardi

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this study was to investigate intrathecal production and affinity distributions of Epstein-Barr virus (EBV)-specific antibodies in multiple sclerosis (MS) and controls. Methods: Cerebrospinal fluid (CSF) and serum concentrations, quantitative intrathecal synthesis, oligoclonal bands (OCB) patterns and affinity distributions of anti-Epstein Barr virus (EBV) antibodies were evaluated in 100 relapsing-remitting MS (RRMS) patients and 200 age- and sex-matched controls with other inflammatory neurological disorders (OIND) and other noninflammatory neurological disorders (NIND). Results: Levels of anti-EBNA-1 and anti-viral capsid antigen (VCA) IgG were different in both the CSF (P

Original languageEnglish
Pages (from-to)188
Number of pages1
JournalJournal of Neuroinflammation
DOIs
Publication statusAccepted/In press - Nov 13 2014

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Neurology
  • Immunology

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    Castellazzi, M., Contini, C., Tamborino, C., Fasolo, F., Roversi, G., Seraceni, S., Rizzo, R., Baldi, E., Tola, M. R., Bellini, T., Granieri, E., & Fainardi, E. (Accepted/In press). Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies. Journal of Neuroinflammation, 188. https://doi.org/10.1186/s12974-014-0188-1