Equine and porcine bone substitutes in maxillary sinus augmentation

A histological and immunohistochemical analysis of VEGF expression

Stefano Tetè, Vincenzo Luca Zizzari, Raffaele Vinci, Susi Zara, Umberto Di Tore, Marco Manica, Amelia Cataldi, Carmen Mortellaro, Adriano Piattelli, Enrico Gherlone

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The aim of this work was to investigate the morphological structure and the expression of vascular endothelial growth factor (VEGF) after maxillary sinus augmentation through equine and porcine bone substitutes in humans.Ten patients showing edentulous posterior maxilla underwent maxillary sinus augmentation through particulate equine bone substitute and 10 patients through particulate porcine bone substitute. At the moment of implants insertion, 6 months after grafting, bone specimens were withdrawn and processed for morphological and immunohistochemical analyses.Notwithstanding the almost comparable clinical performances of both bone substitutes, histological results showed a better integration when an equine bone substitute was used compared to a porcine one. In particular, evident signs of particles resorption were observed in equine bone substitute group specimens compared to porcine ones. Immunohistochemical analysis showed a statistically significant increase of VEGF expression in equine compared to porcine bone substitute group specimens.These results showed both bone substitutes to achieve comparable clinical performance, indicating their successful use for bone regenerative procedures. However, in the same experimental time, equine group specimens showed evident resorption phenomena, whereas no or little signs of resorption were evident in the porcine group specimens. However, a more rapid and intense vascularization was achieved in equine bone substitute group, as demonstrated by immunohistochemical analysis for VEGF expression. Even if differences in vascularization significantly affect the clinical performance of a heterologous bone substitute, its ability to be resorbed is also very important in influencing long-term integration and long-term predictability of implant-prosthetic rehabilitation in regenerated sites.

Original languageEnglish
Pages (from-to)835-839
Number of pages5
JournalJournal of Craniofacial Surgery
Volume25
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Bone Substitutes
Maxillary Sinus
Vascular Endothelial Growth Factor A
Horses
Swine
Bone Transplantation
Maxilla
Rehabilitation

Keywords

  • Equine bone substitute
  • Immunohistochemical analysis
  • Maxillary sinus augmentation
  • Porcine bone substitute
  • VEGF

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Equine and porcine bone substitutes in maxillary sinus augmentation : A histological and immunohistochemical analysis of VEGF expression. / Tetè, Stefano; Zizzari, Vincenzo Luca; Vinci, Raffaele; Zara, Susi; Di Tore, Umberto; Manica, Marco; Cataldi, Amelia; Mortellaro, Carmen; Piattelli, Adriano; Gherlone, Enrico.

In: Journal of Craniofacial Surgery, Vol. 25, No. 3, 2014, p. 835-839.

Research output: Contribution to journalArticle

Tetè, Stefano ; Zizzari, Vincenzo Luca ; Vinci, Raffaele ; Zara, Susi ; Di Tore, Umberto ; Manica, Marco ; Cataldi, Amelia ; Mortellaro, Carmen ; Piattelli, Adriano ; Gherlone, Enrico. / Equine and porcine bone substitutes in maxillary sinus augmentation : A histological and immunohistochemical analysis of VEGF expression. In: Journal of Craniofacial Surgery. 2014 ; Vol. 25, No. 3. pp. 835-839.
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