TY - JOUR
T1 - ER-alpha and ER-beta expression in differentiated thyroid cancer
T2 - relation with tumor phenotype across the TNM staging and peri-tumor inflammation
AU - Magri, Flavia
AU - Capelli, Valentina
AU - Gaiti, Margherita
AU - Villani, Laura
AU - Zerbini, Francesca
AU - La Manna, Luigi
AU - Rotondi, Mario
AU - Chiovato, Luca
PY - 2015/10/22
Y1 - 2015/10/22
N2 - Thyroid cancer may express estrogen receptors (ERs) and various grades of peri-tumor inflammation. The aim of the study was to evaluate the expression of ERs in relation to the TNM stage and peri-tumor inflammatory infiltrate in differentiated thyroid cancers. 127 patients (109 females, 18 males) with differentiated thyroid cancer (T1 = 91, T2 = 18, T3 = 11, T4 = 7) were evaluated. In tumors and in the correspondent extra-tumor parenchyma, ERs expression was evaluated by immunohistochemistry. In 114 tumors and correspondent peri-tumor tissues, the presence of inflammatory infiltration was also recorded. ER-alpha expression was higher in clinical than in incidental tumors of the T1 subgroup (p = 0.037), and was associated with capsular invasion in T2 tumors (p
AB - Thyroid cancer may express estrogen receptors (ERs) and various grades of peri-tumor inflammation. The aim of the study was to evaluate the expression of ERs in relation to the TNM stage and peri-tumor inflammatory infiltrate in differentiated thyroid cancers. 127 patients (109 females, 18 males) with differentiated thyroid cancer (T1 = 91, T2 = 18, T3 = 11, T4 = 7) were evaluated. In tumors and in the correspondent extra-tumor parenchyma, ERs expression was evaluated by immunohistochemistry. In 114 tumors and correspondent peri-tumor tissues, the presence of inflammatory infiltration was also recorded. ER-alpha expression was higher in clinical than in incidental tumors of the T1 subgroup (p = 0.037), and was associated with capsular invasion in T2 tumors (p
KW - Estrogen receptor
KW - Risk assessment
KW - Thyroid cancer
KW - Tumoral inflammation
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UR - http://www.scopus.com/inward/citedby.url?scp=84929951228&partnerID=8YFLogxK
U2 - 10.1007/s12020-014-0457-x
DO - 10.1007/s12020-014-0457-x
M3 - Article
C2 - 25338203
AN - SCOPUS:84929951228
VL - 49
SP - 429
EP - 435
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 2
ER -