ER-alpha and ER-beta expression in differentiated thyroid cancer: relation with tumor phenotype across the TNM staging and peri-tumor inflammation

Flavia Magri; Valentina Capelli; Margherita Gaiti; Laura Villani; Francesca Zerbini; Luigi La Manna; Mario Rotondi; Luca Chiovato

doi:10.1007/s12020-014-0457-x

ER-alpha and ER-beta expression in differentiated thyroid cancer: relation with tumor phenotype across the TNM staging and peri-tumor inflammation

Flavia Magri, Valentina Capelli, Margherita Gaiti, Laura Villani, Francesca Zerbini, Luigi La Manna, Mario Rotondi, Luca Chiovato

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Thyroid cancer may express estrogen receptors (ERs) and various grades of peri-tumor inflammation. The aim of the study was to evaluate the expression of ERs in relation to the TNM stage and peri-tumor inflammatory infiltrate in differentiated thyroid cancers. 127 patients (109 females, 18 males) with differentiated thyroid cancer (T1 = 91, T2 = 18, T3 = 11, T4 = 7) were evaluated. In tumors and in the correspondent extra-tumor parenchyma, ERs expression was evaluated by immunohistochemistry. In 114 tumors and correspondent peri-tumor tissues, the presence of inflammatory infiltration was also recorded. ER-alpha expression was higher in clinical than in incidental tumors of the T1 subgroup (p = 0.037), and was associated with capsular invasion in T2 tumors (p

Original language	English
Pages (from-to)	429-435
Number of pages	7
Journal	Endocrine
Volume	49
Issue number	2
DOIs	https://doi.org/10.1007/s12020-014-0457-x
Publication status	Published - Oct 22 2015

Keywords

Estrogen receptor
Risk assessment
Thyroid cancer
Tumoral inflammation

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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10.1007/s12020-014-0457-x

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title = "ER-alpha and ER-beta expression in differentiated thyroid cancer: relation with tumor phenotype across the TNM staging and peri-tumor inflammation",

abstract = "Thyroid cancer may express estrogen receptors (ERs) and various grades of peri-tumor inflammation. The aim of the study was to evaluate the expression of ERs in relation to the TNM stage and peri-tumor inflammatory infiltrate in differentiated thyroid cancers. 127 patients (109 females, 18 males) with differentiated thyroid cancer (T1 = 91, T2 = 18, T3 = 11, T4 = 7) were evaluated. In tumors and in the correspondent extra-tumor parenchyma, ERs expression was evaluated by immunohistochemistry. In 114 tumors and correspondent peri-tumor tissues, the presence of inflammatory infiltration was also recorded. ER-alpha expression was higher in clinical than in incidental tumors of the T1 subgroup (p = 0.037), and was associated with capsular invasion in T2 tumors (p ",

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AU - Magri, Flavia

AU - Capelli, Valentina

AU - Gaiti, Margherita

AU - Villani, Laura

AU - Zerbini, Francesca

AU - La Manna, Luigi

AU - Rotondi, Mario

AU - Chiovato, Luca

PY - 2015/10/22

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KW - Risk assessment

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ER-alpha and ER-beta expression in differentiated thyroid cancer: relation with tumor phenotype across the TNM staging and peri-tumor inflammation

Abstract

Keywords

ASJC Scopus subject areas

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