ER-alpha and ER-beta expression in differentiated thyroid cancer: relation with tumor phenotype across the TNM staging and peri-tumor inflammation

Flavia Magri, Valentina Capelli, Margherita Gaiti, Laura Villani, Francesca Zerbini, Luigi La Manna, Mario Rotondi, Luca Chiovato

Research output: Contribution to journalArticlepeer-review

Abstract

Thyroid cancer may express estrogen receptors (ERs) and various grades of peri-tumor inflammation. The aim of the study was to evaluate the expression of ERs in relation to the TNM stage and peri-tumor inflammatory infiltrate in differentiated thyroid cancers. 127 patients (109 females, 18 males) with differentiated thyroid cancer (T1 = 91, T2 = 18, T3 = 11, T4 = 7) were evaluated. In tumors and in the correspondent extra-tumor parenchyma, ERs expression was evaluated by immunohistochemistry. In 114 tumors and correspondent peri-tumor tissues, the presence of inflammatory infiltration was also recorded. ER-alpha expression was higher in clinical than in incidental tumors of the T1 subgroup (p = 0.037), and was associated with capsular invasion in T2 tumors (p 

Original languageEnglish
Pages (from-to)429-435
Number of pages7
JournalEndocrine
Volume49
Issue number2
DOIs
Publication statusPublished - Oct 22 2015

Keywords

  • Estrogen receptor
  • Risk assessment
  • Thyroid cancer
  • Tumoral inflammation

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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