ERAAP modulation: A possible novel strategy for cancer immunotherapy?

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recent findings demonstrate that loss of ERAAP, an endoplasmic reticulum aminopeptidase involved in antigen processing, plays a key role in stimulating anti-tumor innate and adaptive immune responses. We show that MHC class I molecules produced in the absence of ERAAP retain their capability of presenting antigens to CD8+ T cells, but not of inhibiting NK cells.

Original languageEnglish
Pages (from-to)81-82
Number of pages2
JournalOncoImmunology
Volume1
Issue number1
DOIs
Publication statusPublished - 2012

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CD8 Antigens
Aminopeptidases
Antigen Presentation
Adaptive Immunity
Innate Immunity
Natural Killer Cells
Endoplasmic Reticulum
Immunotherapy
T-Lymphocytes
Neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

ERAAP modulation : A possible novel strategy for cancer immunotherapy? / Fruci, Doriana; Locatelli, Franco; Cifaldi, Loredana.

In: OncoImmunology, Vol. 1, No. 1, 2012, p. 81-82.

Research output: Contribution to journalArticle

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