ERAAP modulation: A possible novel strategy for cancer immunotherapy?

Doriana Fruci, Franco Locatelli, Loredana Cifaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Recent findings demonstrate that loss of ERAAP, an endoplasmic reticulum aminopeptidase involved in antigen processing, plays a key role in stimulating anti-tumor innate and adaptive immune responses. We show that MHC class I molecules produced in the absence of ERAAP retain their capability of presenting antigens to CD8+ T cells, but not of inhibiting NK cells.

Original languageEnglish
Pages (from-to)81-82
Number of pages2
JournalOncoImmunology
Volume1
Issue number1
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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