Eradication of hepatitis C virus infection disclosing a previously hidden, underlying autoimmune hepatitis: Autoimmune hepatitis and HCV

Valentina Cacciato, Edoardo Casagrande, Giorgia Bodini, Manuele Furnari, Elisa Marabotto, Federica Grillo, Edoardo G. Giannini

Research output: Contribution to journalLetter


Chronic hepatitis C virus (HCV) infection and autoimmune disorders show a complex interplay, with HCV often being identified as the trigger of autoimmune phenomena or diseases. While there is evidence of successful HCV treatment with direct-acting antivirals (DAA) in patients with concomitant HCV and autoimmune hepatitis (AIH), there are also sparse reports of AIH developing during, or following, DAA treatment. Here we report a case of a patient with suspected concomitant HCV and AIH who underwent liver biopsy but showed no histological hallmarks of autoimmunity. The patient later developed a hepatitic flare following DAA-induced viral clearance, and a second liver biopsy showed features compatible with AIH. Response to corticosteroid and azathioprine treatment was seen. This reports demonstrates that patients with features of auto-reactivity and HCV after DAA-induced viral clearance require careful follow-up.

Original languageEnglish
Pages (from-to)222-225
Number of pages4
JournalAnnals of Hepatology
Issue number2
Publication statusPublished - Mar 1 2020



  • Autoimmunity
  • Direct acting antivirals
  • Sustained virological response
  • Treatment

ASJC Scopus subject areas

  • Hepatology

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