Disfunzione erettile nella sclerosi multipla. Risultati clinici del trattamento con Sildenafil

Translated title of the contribution: Erectil dysfunction in multiple sclerosis. Clinical data on the treatment with Sildenafil

Angelo Ghezzi, Silvana Maria Baldini, Gian Mario Malvestiti, Vittorio Martinelli, Enrico Montanari, Antonio Savino, Mauro Zaffaroni, Adelio Zibetti

Research output: Contribution to journalArticle


Sildenafil is an effective drug for erectile dysfunction (ED) of various causes, including neurological diseases. We evaluated the efficacy of sildenafil in an open collaborative study of patients affected by multiple sclerosis (MS). Forty patients affected by MS (mean age 43.7±8.3 years, mean disease duration 10.3±6.9 years) complaining of ED for at least 6 months (mean duration of ED 3.8±2.1 years) were studied. ED was scored by the International Index of Erectile Function-5 (IIEF-5). Sildenafil was given at a fixed dose of 50 mg., taken 1 hour before sexual activity. Results to treatment were evaluated after 8 administrations/after 3 months, asking the patients if the scores of at least 4 questions increased. The same evaluation was conducted on patient's partners. Four patients had no sexual activity in the following 3 months and did not answer to the questionnaire. The mean basal score of the IIEF-5 was 11±4.7, ranging fron 6 to 18; ED was diagnosed if IIEF-5 score was

Original languageItalian
Pages (from-to)157-161
Number of pages5
JournalRivista di Neurobiologia
Issue number3
Publication statusPublished - 2001


ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ghezzi, A., Baldini, S. M., Malvestiti, G. M., Martinelli, V., Montanari, E., Savino, A., Zaffaroni, M., & Zibetti, A. (2001). Disfunzione erettile nella sclerosi multipla. Risultati clinici del trattamento con Sildenafil. Rivista di Neurobiologia, 47(3), 157-161.