TY - JOUR
T1 - Erectile Dysfunction Is Common among Men with Acromegaly and Is Associated with Morbidities Related to the Disease
AU - Lotti, Francesco
AU - Rochira, Vincenzo
AU - Pivonello, Rosario
AU - Santi, Daniele
AU - Galdiero, Mariano
AU - Maseroli, Elisa
AU - Balestrieri, Antonio
AU - Faustini-Fustini, Marco
AU - Peri, Alessandro
AU - Sforza, Alessandra
AU - Colao, Annamaria
AU - Maggi, Mario
AU - Corona, Giovanni
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Introduction: The prevalence of erectile dysfunction (ED) and its correlates in men with acromegaly has never been investigated. Aim: The aim of this study was to evaluate sexual function in men with acromegaly. Methods: Multicenter-based, retrospective analysis of a nonselected series of 57 acromegalic subjects (mean age: 52.7±14.2 years) was performed. Acromegalic subjects reporting ED (n=24) were compared with matched ED patients without acromegaly or pituitary disease (controls), selected from a cohort of more than 4,000 subjects enrolled in the Florence Sexual Medicine and Andrology Unit. Main Outcome Measures: Patients were interviewed using Structured Interview on Erectile Dysfunction (SIEDY) structured interview, a 13-item tool for the assessment of ED-related morbidities. Several clinical and biochemical parameters were taken. Penile color Doppler ultrasound (PCDU) was performed in a subgroup of 37 acromegalic subjects. Results: ED was reported by 42.1% of acromegalic subjects. After adjusting for age and testosterone, acromegalic subjects with ED had a higher prevalence of hypertension and more often reported an impairment of sleep-related erections and a longer smoking habit. Accordingly, acromegaly-associated ED was characterized by a higher organic component and worse PCDU parameters. No relationship between ED and testosterone levels or other acromegaly-related parameters was found. However, acromegalic subjects with severe ED reported a longer disease duration. In a case-control analysis, comparing acromegalic subjects with ED-matched controls free from acromegaly (1:5 ratio), acromegalic men had a worse ED problem and a higher organic component of ED, as derived from SIEDY score. In line with these data, acromegalic patients with ED had a higher prevalence of major adverse cardiovascular events history at enrollment and lower PCDU parameters. Conclusions: Subjects with complicated acromegaly are at an increased risk of developing ED, especially those with cardiovascular morbidities. Our data suggest including a sexual function evaluation in routine acromegaly follow-up.
AB - Introduction: The prevalence of erectile dysfunction (ED) and its correlates in men with acromegaly has never been investigated. Aim: The aim of this study was to evaluate sexual function in men with acromegaly. Methods: Multicenter-based, retrospective analysis of a nonselected series of 57 acromegalic subjects (mean age: 52.7±14.2 years) was performed. Acromegalic subjects reporting ED (n=24) were compared with matched ED patients without acromegaly or pituitary disease (controls), selected from a cohort of more than 4,000 subjects enrolled in the Florence Sexual Medicine and Andrology Unit. Main Outcome Measures: Patients were interviewed using Structured Interview on Erectile Dysfunction (SIEDY) structured interview, a 13-item tool for the assessment of ED-related morbidities. Several clinical and biochemical parameters were taken. Penile color Doppler ultrasound (PCDU) was performed in a subgroup of 37 acromegalic subjects. Results: ED was reported by 42.1% of acromegalic subjects. After adjusting for age and testosterone, acromegalic subjects with ED had a higher prevalence of hypertension and more often reported an impairment of sleep-related erections and a longer smoking habit. Accordingly, acromegaly-associated ED was characterized by a higher organic component and worse PCDU parameters. No relationship between ED and testosterone levels or other acromegaly-related parameters was found. However, acromegalic subjects with severe ED reported a longer disease duration. In a case-control analysis, comparing acromegalic subjects with ED-matched controls free from acromegaly (1:5 ratio), acromegalic men had a worse ED problem and a higher organic component of ED, as derived from SIEDY score. In line with these data, acromegalic patients with ED had a higher prevalence of major adverse cardiovascular events history at enrollment and lower PCDU parameters. Conclusions: Subjects with complicated acromegaly are at an increased risk of developing ED, especially those with cardiovascular morbidities. Our data suggest including a sexual function evaluation in routine acromegaly follow-up.
KW - Cardio-Metabolic Morbidities
KW - Erectile Dysfunction
KW - Major Adverse Cardiovascular Events
KW - Men with Acromegaly
KW - Penile Color Doppler Ultrasound
KW - Sexual Function
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U2 - 10.1111/jsm.12859
DO - 10.1111/jsm.12859
M3 - Article
C2 - 25736192
AN - SCOPUS:84929504377
VL - 12
SP - 1184
EP - 1193
JO - Journal of Sexual Medicine
JF - Journal of Sexual Medicine
SN - 1743-6095
IS - 5
ER -