Erectile Function Outcome after Bilateral Nerve Sparing Radical Prostatectomy: Which Patients May Be Left Untreated?

Andrea Gallina, Matteo Ferrari, Nazareno Suardi, Umberto Capitanio, Firas Abdollah, Manuela Tutolo, Marco Bianchi, Antonino Saccà, Andrea Salonia, Patrizio Rigatti, Francesco Montorsi, Alberto Briganti

Research output: Contribution to journalArticlepeer-review


Introduction. Several studies have shown that erectile function (EF) recovery in patients undergoing bilateral nerve sparing radical prostatectomy (BNSRP) improves significantly when phosphodiesterase type 5 inhibitors (PDE5) are administered following surgery. Aim. The aim of this article was to identify patients who may recover EF after retropubic BNSRP (BNSRRP) without PDE5. Methods. We included 293 patients treated with BNSRRP at a single center. Postoperative EF recovery was defined as an EF domain score of the International Index of Erectile Function (IIEF) ≥22. No patient received any treatment for postoperative erectile dysfunction (ED). Kaplan-Meier curves assessed time to EF recovery according to patient age, preoperative EF, and Charlson comorbidity index (CCI). Univariable and multivariable Cox regression models tested the association between predictors and EF recovery. Finally, the rate of EF recovery of untreated patients after BNSRP was compared with a subset of patients with similar preoperative characteristics but receiving PDE5. Main Outcome Measure. The main outcome measure of this article was the IIEF-EF domain score. Results. Overall, 105/293 (35.8%) reached an IIEF-EF ≥22 after a mean follow-up of 26.8months. At multivariable analyses, age, preoperative IIEF-EF, and CCI achieved independent predictor status (all P≤0.04). Patients 70years (P

Original languageEnglish
Pages (from-to)903-908
Number of pages6
JournalJournal of Sexual Medicine
Issue number3
Publication statusPublished - Mar 2012


  • Erectile Function
  • Radical Prostatectomy
  • Untreated Patients

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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