Abstract
Previous studies showed a higher O2 cost of exercise, and therefore, a reduced exercise tolerance in patients with obesity during constant work rate (CWR) exercise compared with healthy subjects. Among the ergogenic effects of dietary nitrate (NO‒ 3) supplementation in sedentary healthy subjects, a reduced O2 cost and enhanced exercise tolerance have often been demonstrated. The aim of this study was to evaluate the effects of beetroot juice (BR) supplementation, rich in NO‒ 3, on physiological variables associated with exercise tolerance in adolescents with obesity. In a double-blind, randomized crossover study, 10 adolescents with obesity (8 girls, 2 boys; age + 16 ± 1 yr; body mass index + 35.2 ± 5.0 kg/m2) were tested after 6 days of supplementation with BR (5 mmol NO‒ 3 per day) or placebo (PLA). Following each supplementation period, patients carried out two repetitions of 6-min moderate-intensity CWR exercise and one severe-intensity CWR exercise until exhaustion. Plasma NO3 ‒ concentration was significantly higher in BR versus PLA (108 ± 37 vs. 15 ± 5 μM, P < 0.0001). The O2 cost of moderate-intensity exercise was‒1·W‒1not different in BR versus PLA (13.3 ± 1.7 vs. 12.9 ± 1.1 ml·min, P + 0.517). During severe-intensity exercise, signs of a reduced amplitude of the O2 uptake slow component were observed in BR, in association with a significantly longer time to exhaustion (561 ± 198 s in BR vs. 457 ± 101 s in PLA, P + 0.0143). In obese adolescents, short-term dietary NO‒ 3 supplementation is effective in improving exercise tolerance during severe-intensity exercise. This may prove to be useful in counteracting early fatigue and reduced physical activity in this at-risk population.
| Original language | English |
|---|---|
| Pages (from-to) | R453-R460 |
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 315 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1 2018 |
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Keywords
- Endurance exercise
- Nitric oxide
- O uptake kinetics
- Obesity
- Oxidative metabolism
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. / Rasica, Letizia; Porcelli, Simone; Marzorati, Mauro; Salvadego, Desy; Vezzoli, Alessandra; Agosti, Fiorenza; De Col, Alessandra; Tringali, Gabriella; Jones, Andrew M.; Sartorio, Alessandro; Grassi, Bruno.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 315, No. 3, 01.09.2018, p. R453-R460.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents
AU - Rasica, Letizia
AU - Porcelli, Simone
AU - Marzorati, Mauro
AU - Salvadego, Desy
AU - Vezzoli, Alessandra
AU - Agosti, Fiorenza
AU - De Col, Alessandra
AU - Tringali, Gabriella
AU - Jones, Andrew M.
AU - Sartorio, Alessandro
AU - Grassi, Bruno
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Previous studies showed a higher O2 cost of exercise, and therefore, a reduced exercise tolerance in patients with obesity during constant work rate (CWR) exercise compared with healthy subjects. Among the ergogenic effects of dietary nitrate (NO‒ 3) supplementation in sedentary healthy subjects, a reduced O2 cost and enhanced exercise tolerance have often been demonstrated. The aim of this study was to evaluate the effects of beetroot juice (BR) supplementation, rich in NO‒ 3, on physiological variables associated with exercise tolerance in adolescents with obesity. In a double-blind, randomized crossover study, 10 adolescents with obesity (8 girls, 2 boys; age + 16 ± 1 yr; body mass index + 35.2 ± 5.0 kg/m2) were tested after 6 days of supplementation with BR (5 mmol NO‒ 3 per day) or placebo (PLA). Following each supplementation period, patients carried out two repetitions of 6-min moderate-intensity CWR exercise and one severe-intensity CWR exercise until exhaustion. Plasma NO3 ‒ concentration was significantly higher in BR versus PLA (108 ± 37 vs. 15 ± 5 μM, P < 0.0001). The O2 cost of moderate-intensity exercise was‒1·W‒1not different in BR versus PLA (13.3 ± 1.7 vs. 12.9 ± 1.1 ml·min, P + 0.517). During severe-intensity exercise, signs of a reduced amplitude of the O2 uptake slow component were observed in BR, in association with a significantly longer time to exhaustion (561 ± 198 s in BR vs. 457 ± 101 s in PLA, P + 0.0143). In obese adolescents, short-term dietary NO‒ 3 supplementation is effective in improving exercise tolerance during severe-intensity exercise. This may prove to be useful in counteracting early fatigue and reduced physical activity in this at-risk population.
AB - Previous studies showed a higher O2 cost of exercise, and therefore, a reduced exercise tolerance in patients with obesity during constant work rate (CWR) exercise compared with healthy subjects. Among the ergogenic effects of dietary nitrate (NO‒ 3) supplementation in sedentary healthy subjects, a reduced O2 cost and enhanced exercise tolerance have often been demonstrated. The aim of this study was to evaluate the effects of beetroot juice (BR) supplementation, rich in NO‒ 3, on physiological variables associated with exercise tolerance in adolescents with obesity. In a double-blind, randomized crossover study, 10 adolescents with obesity (8 girls, 2 boys; age + 16 ± 1 yr; body mass index + 35.2 ± 5.0 kg/m2) were tested after 6 days of supplementation with BR (5 mmol NO‒ 3 per day) or placebo (PLA). Following each supplementation period, patients carried out two repetitions of 6-min moderate-intensity CWR exercise and one severe-intensity CWR exercise until exhaustion. Plasma NO3 ‒ concentration was significantly higher in BR versus PLA (108 ± 37 vs. 15 ± 5 μM, P < 0.0001). The O2 cost of moderate-intensity exercise was‒1·W‒1not different in BR versus PLA (13.3 ± 1.7 vs. 12.9 ± 1.1 ml·min, P + 0.517). During severe-intensity exercise, signs of a reduced amplitude of the O2 uptake slow component were observed in BR, in association with a significantly longer time to exhaustion (561 ± 198 s in BR vs. 457 ± 101 s in PLA, P + 0.0143). In obese adolescents, short-term dietary NO‒ 3 supplementation is effective in improving exercise tolerance during severe-intensity exercise. This may prove to be useful in counteracting early fatigue and reduced physical activity in this at-risk population.
KW - Endurance exercise
KW - Nitric oxide
KW - O uptake kinetics
KW - Obesity
KW - Oxidative metabolism
UR - http://www.scopus.com/inward/record.url?scp=85052510073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052510073&partnerID=8YFLogxK
U2 - 10.1152/ajpregu.00017.2018
DO - 10.1152/ajpregu.00017.2018
M3 - Article
AN - SCOPUS:85052510073
VL - 315
SP - R453-R460
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 3
ER -