Eribulin in heavily pretreated metastatic breast cancer patients and clinical/biological feature correlations: Impact on the practice

Alessandra Fabi, Luca Moscetti, Mariangela Ciccarese, Miriam Caramanti, Nello Salesi, Nicla La Verde, Michelangelo Russillo, Daniele Generali, Giuseppina Scandurra, Sabrina Vari, Umberto Pacetti, Francesco Cognetti, Diana Giannarelli

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: This multicenter study describes the effectiveness of eribulin in current practice. Patients & methods: In total, 78 patients with advanced metastatic breast cancer, previously treated with two or more chemotherapy lines were enrolled. Results: The median duration of response and disease stability were 7.5 (5.4-9.5) and 8.9 (6.2-11.6) months, respectively, with a clinical benefit (CB) at 6 months in 41% of patients. CB in visceral and nonvisceral metastases were 72.7 and 88.9%, respectively. Eribulin was active also in brain metastases, with 47% CB. The activity was shown in all biological subtypes. Toxicities were manageable. Conclusion: Our study confirms the effectiveness of eribulin mesylate in the treatment of patients with metastatic breast cancer and two or more lines of chemotherapy, in particular in the good disease control at the different metastatic sites.

Original languageEnglish
Pages (from-to)431-438
Number of pages8
JournalFuture Oncology
Volume11
Issue number3
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • brain metastases
  • eribulin
  • metastatic breast cancer
  • triple negative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

Fingerprint

Dive into the research topics of 'Eribulin in heavily pretreated metastatic breast cancer patients and clinical/biological feature correlations: Impact on the practice'. Together they form a unique fingerprint.

Cite this